Cefpodoxime proxetil soft capsule preparation and its preparing method

A technology of cefpodoxime axetil and soft capsule preparations, which is applied in capsule delivery, local antibacterial agents, respiratory diseases, etc., to achieve the effects of improving stability, improving bioavailability, and high bioavailability

Inactive Publication Date: 2005-03-02
北京瑞伊人科技发展有限公司 +1
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is exactly that the dosage form of existing cefpodoxime axetil is suitable for adults to take, to provide a sa

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Put 1kg of gelatin, 350g of glycerin, 1kg of water, an appropriate amount of pigment, and 2.5g of ethylparaben in a plastic tank, then heat the mixture to about 70-80°C, mix well, vacuumize, filter, keep warm and let it stand for a while. use. Take 3g of PEG6000 and 257g of PEG400, heat and melt, then add 40g of cefpodoxime axetil into the mixer, mix thoroughly, measure the content, and set aside. After being compressed in the soft capsule manufacturing machine, the drops are set in the setting machine for finalizing the shape. After washing, the drops are dried at around 30°C for 12 hours.

[0014] According to the process of Example 1, the detailed components can be changed as follows.

Embodiment 2

[0016] Component Quantity (g)

[0017] Cefpodoxime axetil 40

[0018] Hydroxypropyl Cellulose 15

[0019] Vegetable oil 245

Embodiment 3

[0021] Component Quantity (g)

[0022] Cefpodoxime axetil 40

[0023] beeswax 9

[0024] Vegetable oil 251

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses one kind of soft cefpodoxime proxetil capsule and its preparation process. The medicine consists of medicine liquid and capsule shell, the medicine liquid contains cefpodoxime proxetil, matrix and stabilizer, and the capsule shell contains gelatin, glycerin, water, preservative and light screening agent. Compared with available cefpodoxime proxetil preparations, the present invention is even suitable for children and other people incapable of taking care of himself to take and has the advantages of high bioavailability, high stability, accurate content, etc.

Description

technical field [0001] The invention relates to a soft capsule preparation of cefpodoxime axetil and a preparation method thereof, belonging to the technical field of medicines and preparation thereof. technical background [0002] Cefpodoxime proxetil (Cefpodoxime proxetil) is an oral high-efficiency third-generation cephalosporin successfully developed and produced by Sankyo Co., Ltd. in Japan in 1989. Cefpodoxime axetil is the precursor of cefpodoxime (Cefpodoxime), and it shows good antibacterial activity after absorption. Its antibacterial activity lies in its inhibition of bacterial cell wall synthesis and its high stability to β-lactamase. Wide antibacterial spectrum includes traditional drug-resistant pathogenic bacteria, strong antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria, especially highly active against Staphylococcus, Streptococcus, etc., providing excellent Important advantages...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/48A61K31/545A61P11/00A61P11/02A61P11/04A61P13/00A61P17/02A61P27/16A61P31/02
Inventor 庄大伟孙丽红王卓睿王嘉瑜张志宏
Owner 北京瑞伊人科技发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap