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Cefpodoxime proxetil soft capsule preparation and its preparing method

A technology of cefpodoxime axetil and soft capsule preparations, which is applied in capsule delivery, local antibacterial agents, respiratory diseases, etc., to achieve the effects of improving stability, improving bioavailability, and high bioavailability

Inactive Publication Date: 2005-03-02
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is exactly that the dosage form of existing cefpodoxime axetil is suitable for adults to take, to provide a safe and convenient cefpodoxime axetil soft capsule dosage form and preparation process thereof for children and patients who cannot take care of themselves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Put 1kg of gelatin, 350g of glycerin, 1kg of water, an appropriate amount of pigment, and 2.5g of ethylparaben in a plastic tank, then heat the mixture to about 70-80°C, mix well, vacuumize, filter, keep warm and let it stand for a while. use. Take 3g of PEG6000 and 257g of PEG400, heat and melt, then add 40g of cefpodoxime axetil into the mixer, mix thoroughly, measure the content, and set aside. After being compressed in the soft capsule manufacturing machine, the drops are set in the setting machine for finalizing the shape. After washing, the drops are dried at around 30°C for 12 hours.

[0014] According to the process of Example 1, the detailed components can be changed as follows.

Embodiment 2

[0016] Component Quantity (g)

[0017] Cefpodoxime axetil 40

[0018] Hydroxypropyl Cellulose 15

[0019] Vegetable oil 245

Embodiment 3

[0021] Component Quantity (g)

[0022] Cefpodoxime axetil 40

[0023] beeswax 9

[0024] Vegetable oil 251

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PUM

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Abstract

The present invention discloses one kind of soft cefpodoxime proxetil capsule and its preparation process. The medicine consists of medicine liquid and capsule shell, the medicine liquid contains cefpodoxime proxetil, matrix and stabilizer, and the capsule shell contains gelatin, glycerin, water, preservative and light screening agent. Compared with available cefpodoxime proxetil preparations, the present invention is even suitable for children and other people incapable of taking care of himself to take and has the advantages of high bioavailability, high stability, accurate content, etc.

Description

technical field [0001] The invention relates to a soft capsule preparation of cefpodoxime axetil and a preparation method thereof, belonging to the technical field of medicines and preparation thereof. technical background [0002] Cefpodoxime proxetil (Cefpodoxime proxetil) is an oral high-efficiency third-generation cephalosporin successfully developed and produced by Sankyo Co., Ltd. in Japan in 1989. Cefpodoxime axetil is the precursor of cefpodoxime (Cefpodoxime), and it shows good antibacterial activity after absorption. Its antibacterial activity lies in its inhibition of bacterial cell wall synthesis and its high stability to β-lactamase. Wide antibacterial spectrum includes traditional drug-resistant pathogenic bacteria, strong antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria, especially highly active against Staphylococcus, Streptococcus, etc., providing excellent Important advantages...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61P11/00A61P11/02A61P11/04A61P13/00A61P17/02A61P27/16A61P31/02
Inventor 庄大伟孙丽红王卓睿王嘉瑜张志宏
Owner 北京瑞伊人科技发展有限公司
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