Photocureable rapid shaping indirect manufacturing method for controllable microtube structure stand

Abstract

A process for quickly and indirectly preparing the scaffold with controllable microchannel structure by optical solidifying method includes such steps as acquiring actual CT data, using 3D CAD software to reconfigure the profile of bone, designing internal microchannels and controlling the size, shaping, direction, branches and mutual communication of microchannels, using optical solidifying apparatus to manufacture resin mould, filling biologic materiall, solidifying, and thermal decompsing to remove said resin mould.

Description

technical field

[0001] The invention belongs to the light-curing rapid prototyping manufacturing technology, relates to the preparation of a tissue engineering support, in particular to the indirect manufacturing method of the light-curing rapid prototyping of the controllable micro-pipe structure support. Background technique

[0002] As we all know, in bone tissue engineering, as a temporary carrier of cells, the scaffold should not only have the same appearance as the replaced part, but also the internal microstructure must meet the following conditions: it is conducive to the growth of cells / tissues, and the absorption of nutrients and blood. supply, which is conducive to the exchange of gases, etc. Because the shape of the bone is very complex, it is very difficult to manufacture a bracket that matches the shape of the bone using traditional processing methods. The pore-making methods of traditional scaffolds (such as: phase separation / emulsification, fiber bonding, so...

Examples

specific Embodiment

[0026] For pictures of the bionic scaffolds for the distal femur of dogs prepared by the invented method, see figure 2 , the process is as image 3 shown. According to the clinical CT data, after a series of image processing, the continuous CT images are input into the Mimics software in order to obtain the point cloud data of the distal femur of the dog, and store them in IGES format files, and then input the obtained point cloud data into the Surface The software performs surface reconstruction. Due to the complex shape of the joint surface of the distal femur, large curvature changes, and certain deviations in the obtained point cloud data, if only traditional faceting methods are used, such as: Loft, Sweep, Through Curve and Through CurveMesh, etc., cannot effectively construct high-quality joint surfaces. Therefore, the three-dimensional reconstruction of the joint surface is completed by using the two faceting methods of point data paste and freeform surface (fit free...

technical field

[0001] The invention belongs to the light-curing rapid prototyping manufacturing technology, relates to the preparation of a tissue engineering support, in particular to the indirect manufacturing method of the light-curing rapid prototyping of the controllable micro-pipe structure support. Background technique

[0002] As we all know, in bone tissue engineering, as a temporary carrier of cells, the scaffold should not only have the same appearance as the replaced part, but also the internal microstructure must meet the following conditions: it is conducive to the growth of cells / tissues, and the absorption of nutrients and blood. supply, which is conducive to the exchange of gases, etc. Because the shape of the bone is very complex, it is very difficult to manufacture a bracket that matches the shape of the bone using traditional processing methods. The pore-making methods of traditional scaffolds (such as: phase separation / emulsification, fiber bonding, so...

Examples

specific Embodiment

[0026] For pictures of the bionic scaffolds for the distal femur of dogs prepared by the invented method, see figure 2 , the process is as image 3 shown. According to the clinical CT data, after a series of image processing, the continuous CT images are input into the Mimics software in order to obtain the point cloud data of the distal femur of the dog, and store them in IGES format files, and then input the obtained point cloud data into the Surface The software performs surface reconstruction. Due to the complex shape of the joint surface of the distal femur, large curvature changes, and certain deviations in the obtained point cloud data, if only traditional faceting methods are used, such as: Loft, Sweep, Through Curve and Through CurveMesh, etc., cannot effectively construct high-quality joint surfaces. Therefore, the three-dimensional reconstruction of the joint surface is completed by using the two faceting methods of point data paste and freeform surface (fit free...

Images