Photoelectric detection circuit for single photon counting instrument

A technology of single-photon counting and photoelectric detection, which is applied in the direction of lamp circuit layout, chemiluminescence/bioluminescence, light source, etc., can solve the problems of limiting the scope of application and being unable to correctly judge the luminous intensity of the sample under inspection, and achieve performance expansion, The effect of less increase and simple circuit

Inactive Publication Date: 2005-06-01
BEIJING YUANDE BIO MEDICAL ENG
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  • Claims
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Problems solved by technology

Obviously, the count output value at this time cannot be used to correctly judge the luminou

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  • Photoelectric detection circuit for single photon counting instrument

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Example Embodiment

[0026] Such as figure 1 As shown, according to the embodiment of the present invention, in the photodetection circuit, the photomultiplier tube 1 consists of a photocathode K in a vacuum cover and a series of dynodes D 1 ...D n It is composed of an anode P. When the photon hits the photocathode K, due to the photoelectric effect, the photocathode K emits electrons, and these electrons are generated by another series of dynodes D 1 ...D n Speed ​​up and generate more electrons on each dynode. According to the size of the accelerating voltage and the number of dynodes, this cascading effect can cause the photons that hit the first cathode to produce 10 5 To 10 7 Electrons. Finally, an amplified electrical signal is output on the anode for measurement. The anode P of the photomultiplier tube 1 is connected to the preamplifier 2. The preamplifier 2 is used to amplify the electrical signal output by the electro-optic multiplier tube 1. The output terminal of the preamplifier 2 is conne...

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Abstract

The photoelectric detection circuit for single photon counting instrument includes one photo detector for receiving photons and outputting electric signal; one pre-amplifier for amplifying the electric signal the photo detector outputs; one voltage comparator for cutting off the noise signal and converting the analog signal over certain level into electric pulse signal; and one counter for counting the electric pulses within certain time interval and outputting the counting number. The photoelectric detection circuit features its low-pass filter for low-pass filtering the electric signal the pre-amplifier outputs to output one DC signal, and the DC amplifier for amplifying the DC signal the low-pass filter outputs to output one current average value.

Description

technical field [0001] The invention relates to a single photon counter, in particular to a photoelectric detection circuit for the single photon counter. Background technique [0002] The determination of various hormones, drugs, vitamins, tumors and infection-related substances has become one of the routine inspection tasks in hospitals. However, the radioimmunoassay technology used in the past has problems such as short half-life, not conducive to storage, easy to cause harm to operators and the environment, and insufficient detection sensitivity. In the 1990s, a photobiological labeling and detection technology represented by chemiluminescence appeared, which was not only simple, fast, and safe, but also had higher sensitivity, so it was quickly applied to clinical diagnosis and other aspects. [0003] A single photon counter is a device that is matched with corresponding detection reagents and used for detection by chemiluminescence. It uses the single photon counting...

Claims

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Application Information

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IPC IPC(8): G01N21/76H05B37/02
CPCY02B20/40
Inventor 于晋生兰江吴晓东
Owner BEIJING YUANDE BIO MEDICAL ENG
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