Spray agent of dried powder in use for diminishing inflammation of mucous membrane and preparation method

A technology of spray and dry powder, which is applied in the fields of powder transportation, digestive system, and pharmaceutical formula, which can solve the problems of inconvenient use and few applications, and achieve stable and reliable products

Inactive Publication Date: 2005-06-15
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Yunnan Baiyao, which has a history of more than 100 years, has many unique features in trauma medicine, but its application in mucous membranes is limited by its dosage form and the problems of the drug itself, so far it has not been used much and is inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of Yunnan Baiyao Dry Powder Spray

[0020] Step 1. Separation of active ingredients of Yunnan Baiyao:

[0021] Take 1 kg of Yunnan Baiyao powder, extract with 70% ethanol 8, 6, and 6 times heat reflux for 1 hour three times, combine the extracts, concentrate to 50% amount, decolorize with 0.1% solution amount of activated carbon, short (10cm) The silica gel column was used to remove impurities once, concentrated to 20% of the amount, left overnight at 5-10°C, filtered by ultrafiltration, concentrated to dryness in a vacuum, and about 70 g of effective antibacterial, hemostatic and anti-inflammatory parts of Yunnan Baiyao were obtained (yield ~ 7%);

[0022] Step 2, the preparation of Yunnan Baiyao extract superfine powder:

[0023] Under the condition of grade 10,000, add 50 g of the antibacterial, hemostatic and anti-inflammatory effective part of Yunnan Baiyao extracted above to 250 g of excipient chitin, grind and mix well, and carry out airflow (or othe...

Embodiment 2

[0027] Preparation of Yunnan Baiyao Dry Powder Spray

[0028] Step 1, with embodiment 1;

[0029] Step 2, the preparation of Yunnan Baiyao extract superfine powder:

[0030] Under the condition of 10,000 grades, 50g of the effective part of Yunnan Baiyao extracted above for antibacterial, hemostatic and anti-inflammation was added with 100g of polyacrylic acid carbomer (CP), 150g of β-cyclodextrin, 0.05g of Artemisia annua oil, finely ground and mixed Uniformly, carry out airflow type (or other) micronized pulverization. 290g of the required uniform ultra-fine semi-finished product can be obtained;

[0031] Step 3, the preparation of Yunnan Baiyao extract dry powder spray:

[0032] Under the condition of 10,000 grades, the above-mentioned Yunnan Baiyao extract ultrafine powder is encapsulated in a capsule (or bubble-eye type / or rod-type) spray drug container according to 0.1g per capsule, and the Yunnan Baiyao extract can be obtained Dry powder spray 2900 sprays, each spra...

Embodiment 3

[0034] Preparation of Yunnan Baiyao Dry Powder Spray

[0035] Step 1, with embodiment 1;

[0036] Step 2, the preparation of Yunnan Baiyao extract superfine powder:

[0037] Under the condition of 10,000 grades, add 50 g of the antibacterial, hemostatic and anti-inflammatory effective parts of Yunnan Baiyao extracted above to 70 g of hypromellose, 1 g of sodium glycocholate, and 0.2 ml of woody oil, grind and mix evenly, and perform air flow ( or other) ultrafine pulverization. The required uniform ultra-fine semi-finished product 110g can be obtained.

[0038] Step 3, the preparation of Yunnan Baiyao extract dry powder spray:

[0039] Under the condition of 10,000 grades, the above-mentioned Yunnan Baiyao extract ultrafine powder is encapsulated in a capsule (or bubble-eye type / or rod-type) spray drug container according to 0.3g per capsule, and the Yunnan Baiyao extract can be obtained. Dry powder spray 366 sprays, each spray (containing ~0.14g of effective extract).

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Abstract

A powder spray for relieving the inflammation of mucosa is prepared from Yunnan white medicine and the filming auxiliary with high affinity to mucosa. Its advantages are high curative effect and no irritation.

Description

technical field [0001] The invention relates to a dry powder spray for mucous membrane anti-inflammation with antibacterial and protective effects on mucous membrane inflammation and swelling and pain and a production method. Background technique [0002] Yunnan Baiyao, which has a history of more than 100 years, has many unique features in traumatic medicine, but its application in mucous membranes is limited by its dosage form and the problems of the medicine itself, so far it has not been used much and is inconvenient to use. Now the incidence of mucosal diseases is still relatively high, which brings more pain to patients, such as intractable oral ulcers, which are more common in recurrent aphthous ulcers. It is a localized damage to the oral mucosa with periodic episodic characteristics, and the incidence rate is high. The general population The prevalence rate is not less than 10%. Nasal mucosa, vaginal mucosa incidence is also higher. Yunnan Baiyao has the effects o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/14A61P1/02A61P11/02A61P15/02
Inventor 王京
Owner KUNMING ZIJIAN BIOTECH
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