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Chitosan-calcium alginate gel microsphere soft tissue reinforced material and its preparation method and application

A technology of calcium alginate gel microspheres and calcium alginate, applied to the application of the above-mentioned materials, chitosan-calcium alginate gel microsphere soft tissue reinforcement materials, the preparation of the above-mentioned materials can solve the problem of harm to the human body, the production of Achieve high sphericity, maintain strength, and high strength for problems such as granulomas and application limitations

Inactive Publication Date: 2005-06-22
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Implant materials currently used in experimental research and clinical treatment in this area [Document 3: Van Kerrebroeck P, Ter Meulen F, Farrelly E, et al. Treatment of stress urinaryincontinence: recent developments in the role of urethral injection. Urol Res, 2003 ; 30(6): 356-362.] There are 1) polytetrafluoroethylene microspheres, which are easy to migrate in vivo according to literature reports, and can produce granuloma locally; 2) autologous fat, although it has good biocompatibility, but 3) Glutaraldehyde crosslinks bovine collagen, which is prone to allergic reactions, and trace glutaraldehyde residues are harmful to the human body; 4) Silicone resin balls, ceramic microspheres, etc., due to the implantation method and cost reasons, applications are also limited

Method used

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  • Chitosan-calcium alginate gel microsphere soft tissue reinforced material and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0036] Chitosan-calcium alginate gel microsphere soft tissue reinforcement material preparation: under sterile conditions, 2.0% (w / v) sodium alginate solution in 1.0mol / L CaCl 2Under the condition that the solution is a gel bath, the calcium alginate gel microspheres with a particle size of 400-600 μm are prepared by the electrostatic droplet method, and the calcium alginate gel microspheres are mixed with 0.7% (w / v) chitosan The sugar solution was formed into a film at a volume ratio of 1:7, and then mixed with 0.5% (w / v) sodium alginate solution at a volume ratio of 10:20 to obtain a chitosan-calcium alginate gel microsphere soft tissue reinforcing material.

Embodiment 2

[0038] Chitosan-calcium alginate gel microsphere soft tissue reinforcement material preparation: under sterile conditions, 0.5% (w / v) sodium alginate solution in 0.01mol / L CaCl 2 Under the condition that the solution is a gel bath, the calcium alginate gel microspheres with a particle size of mainly 250-800 μm are prepared by the electrostatic droplet method, and the calcium alginate gel microspheres are mixed with 0.2% (w / v) chitosan The sugar solution was formed into a film at a volume ratio of 1:1, and then mixed with 2.0% (w / v) sodium alginate solution at a volume ratio of 10:10 to obtain a chitosan-calcium alginate gel microsphere soft tissue reinforcing material.

Embodiment 3

[0040] Chitosan-calcium alginate gel microsphere soft tissue reinforcement material preparation: under sterile conditions, 1.5% (w / v) sodium alginate solution in 0.1mol / L CaCl 2 Under the condition that the solution is a gel bath, calcium alginate gel microspheres with a particle size of 100-600 μm are prepared by electrostatic droplet method, and the calcium alginate gel microspheres are mixed with 1.0% (w / v) chitosan The sugar solution was formed into a film at a volume ratio of 1:5, and then mixed with a 1.0% (w / v) sodium alginate solution at a volume ratio of 10:15 to obtain a chitosan-calcium alginate gel microsphere soft tissue reinforcing material.

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Abstract

The invention discloses a chitosan-calcium alginate gel microsphere soft tissue reinforced material, its preparation method comprises preparing calcium alginate gel microsphere from sodium alginate solution, forming film from calcium alginate gel microballoon and chitosan, and mixing the chitosan-calcium alginate gel microsphere with sodium alginate solution.

Description

technical field [0001] The invention relates to a soft tissue reinforcing material for local injection and implantation, in particular to a chitosan-calcium alginate gel microsphere soft tissue reinforcing material. [0002] The invention also relates to a method for the preparation of the aforementioned materials. [0003] The invention also relates to the use of the aforementioned materials. Background technique [0004] At present, the treatment of stress urinary incontinence, gastroesophageal reflux disease, unilateral vocal cord paralysis and other diseases caused by local soft tissue structure relaxation mostly adopts surgical suspension and local implantation of reinforcing materials [Document 1: Ghoniem GM, Elgamasy AN, Elsergany R, et al. Grades of intrinsic spincteric deficiency (ISD) associated with female stressurinary incontinence. Int Urogynecol J, 2002: 13(2): 99-105.]. Among them, local injection and implantation of soft tissue reinforcement materials belon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/14A61L31/04C08L5/02C08L5/04
Inventor 马小军许岩王为
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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