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Compound isosorbide mononitrate injectio and its preparing process

A technology of isosorbide dinitrate and injection, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve problems such as no reports on injection formulations.

Inactive Publication Date: 2005-07-06
崔晓廷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the injection form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0005] Embodiment 1: it is made up of 20 grams of isosorbide mononitrate and 25 grams of aspirin. 20 grams of isosorbide mononitrate and 25 grams of aspirin are mixed with 2000 ML of water for injection, and it is made into an injection according to the prior art. The preparation does not add any excipients.

Embodiment 2

[0006] Embodiment 2: It is made up of 20 grams of isosorbide mononitrate and 25 grams of aspirin, and is prepared with 100,000 mL of water for injection during the production process, and is made into a large-capacity infusion according to the prior art.

Embodiment 3

[0007] Example 3: 20 grams of isosorbide mononitrate and 25 grams of aspirin were mixed with an appropriate amount of water for injection, and made into a freeze-dried powder injection according to the prior art. Mannitol can be used as an excipient in this formulation.

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PUM

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Abstract

The invention provides a compound isosorbide mononitrate injectio and its preparing process wherein the injection preparation comprises isosorbide mononitrate and aspirin, whose proportion is isosorbide mononitrate : aspirin = 1-99 : 99-1, the injection includes the forms of injection, freeze-dried powder injection, asepsis powder injection and high volume transfusion. The preparation can serve as a novel medicament for preventing angina pectoris caused by coronary arteriosclerosis or coronary arteriospasm.

Description

Technical field: [0001] The invention provides a compound isosorbide mononitrate injection and a preparation method thereof, belonging to the technical field of medicines and preparation methods thereof. Background technique: [0002] Isosorbide mononitrate is an antianginal drug. It is suitable for the prevention of angina pectoris for coronary heart disease, and also for the treatment after myocardial infarction. Isosorbide mononitrate is the main active metabolite of isosorbide dinitrate. On the one hand, it can increase venous blood volume by dilating peripheral blood vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption; on the other hand, it can improve blood flow supply in ischemic areas by promoting the redistribution of myocardial blood flow. This product attracts rapidly, has high bioavailability, and has a long duration of action. Aspirin has antithrombotic properties in the body: it inhibits cyclooxygenase, reducing the product...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61P9/10
Inventor 崔晓廷
Owner 崔晓廷
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