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Sustained release high calcium formulation and preparation process thereof

A slow-release, high-calcium technology, applied in pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, and medical preparations with non-active ingredients, etc. Fully absorbed, easy to operate and control effects

Inactive Publication Date: 2005-07-06
天津开发区渤海医药贸易公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the calcium products on the market often increase the content of single-dose calcium or require those in need to take it several times a day to meet the daily calcium absorption requirements of the human body, but the actual effect is not satisfactory. Generally speaking, the absorption amount of the human body per unit time is certain, no matter how much calcium is input, the effective absorption amount of the receptors has its certain value, and taking it in equal proportions many times a day is not suitable for children, pregnant women and middle-aged and elderly people. People also have some inconvenience

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Based on 1000 slow-release high-calcium preparations, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; Mix 100g of calcium through a 100-mesh sieve, 20g of lactose through a 80-mesh sieve and 20g of starch powder through a 100-mesh sieve, and then add them to the above-mentioned granulator and process for 50 minutes to obtain the main drug granules with a smooth surface. After the completion, continue to spray 50% sucrose syrup, and add 8g of starch to wrap the main drug protective layer, and then dry the wrapped main drug granules in a vacuum drying oven at 80°C for 3 hours, or ordinary electric drying at 80°C Dry in the box for 6 hours; dissolve 10g of the acrylic resin slow-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 3 g of talcum powder, an auxiliary material for coating, into an appropriate amount of ...

Embodiment 2

[0013] Based on 1000 slow-release high-calcium preparations, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; 100g of calcium passed through a 100 mesh sieve, 15g of polyethylene glycol 6000 passed through a 80 mesh sieve and 13g of pregelatinized starch powder passed through a 100 mesh sieve were mixed evenly and added to the above-mentioned granulator for 50 minutes to obtain a smooth surface. Medicine granules, after the main medicine granules are wrapped, continue to spray 50% sucrose syrup, and add 5g of starch to wrap the main medicine protective layer, and then place the wrapped main medicine granules in a vacuum drying oven at 80°C to dry for 3 hours. Or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 8g of polyvinylpyrrolidone and 12g of hydroxypropyl methylcellulose with 5mL of water respectively with an appropriate amo...

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Abstract

Disclosed is a sustained release high calcium formulation and preparation process, wherein the formulation comprises calcium as active component, slow release material coated outside the active component and adjuvant by the weight ratio of 90-110 : 5-20 : 131-165, the slow release material includes any one to four from acrylic resin, methyl hydroxypropylcellulose, ethyl cellulose, cellulose acetate-phthalate, and polyvinylpyrrolidone.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a sustained-release high-calcium preparation and a preparation method thereof. Background technique [0002] As we all know, calcium is a trace element that the human body must maintain a certain ratio of absorption, especially for children, pregnant women and middle-aged and elderly people. At present, the calcium products on the market often increase the content of single-dose calcium or require those in need to take it several times a day to meet the daily calcium absorption requirements of the human body, but the actual effect is not satisfactory. Generally speaking, the absorption amount of the human body per unit time is certain, no matter how much calcium is input, the effective absorption amount of the receptors has its certain value, and taking it in equal proportions many times a day is not suitable for children, pregnant women and middle-aged and elderly p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/22A61K33/06A61K47/30A61K47/36A61P3/02
Inventor 李立柱杨恩久
Owner 天津开发区渤海医药贸易公司
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