Disinfecting and sterilizing fomulation for vaginal mucosa

A technology for disinfection and sterilization of vaginal mucous membranes, applied in diseases, drug combinations, active ingredients of iodine compounds, etc., can solve the problems of large mucous membrane irritation, poor stability, unstable physical and chemical properties, etc., and achieve the effect of convenient use and definite curative effect

Active Publication Date: 2005-07-06
BEIJING WANHUI DOUBLE CRANE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since iodine is strongly irritating to mucous membranes and has unstable physical and chemical properties, it cannot be directly used for disinfection of vaginal or vulvar mucous membranes.
The reason

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Preparation of cediodine freeze-dried powder, method 1

[0046] 1. Take 12g of potassium iodide, add 40ml of water, add 18g of iodine, grind to dissolve, and set aside.

[0047] 2. Take 75g of β-cyclodextrin, put it in a 1000ml flask, add 300ml of water, heat in a water bath at 60-90°C, stir to dissolve it completely, and set aside.

[0048]3. Add the iodine solution into the prepared β-cyclodextrin solution under stirring, maintain the water bath temperature at 60-90°C, continue to stir for 2 hours, cool down, filter, dry in low-temperature vacuum, and crush the dried product through an 80-mesh sieve. Obtain the iodine-β-cyclodextrin inclusion complex --- cediiodine, the iodine content is 12-20%, and the yield is over 90%.

[0049] 4. The inclusion compound of iodine-β-cyclodextrin was dissolved in purified water with stirring, homogenized by a high-pressure high-speed homogenizer, and the resulting solution was freeze-dried to obtain cediiodine freeze-dried...

Embodiment 2

[0050] Embodiment two preparation cediodine freeze-dried powder, method 2

[0051] 1. Take 18g of iodine, add appropriate amount of ethanol under stirring to make iodine alcohol solution, set aside.

[0052] 2. Take 75g of β-cyclodextrin, put it in a 1000ml flask, add 300ml of water, heat in a water bath at 60-90°C, stir to dissolve it completely, and set aside.

[0053] 3. Add the iodine alcohol solution to the β-cyclodextrin solution under stirring, maintain the temperature of the water bath at 60-90°C, continue to stir for 2 hours, cool down, filter, dry in low-temperature vacuum, and crush the dry matter through an 80-mesh sieve to obtain iodine- β-cyclodextrin inclusion complex --- cediiodine, iodine content 12-20%, yield over 90%.

[0054] 4. The inclusion compound of iodine-β-cyclodextrin was dissolved in purified water under agitation, homogenized in a high-pressure high-speed homogenizer, and the solution was freeze-dried to obtain cediiodine freeze-dried powder. Th...

Embodiment 3

[0055] Example 3 Preparation of Menthol-β Cyclodextrin Inclusion Complex

[0056] At 75°C, cyclodextrin was added to a 500ml flask, and 300ml of water was added thereto. Then heat in a water bath at 75°C and stir to dissolve. Take another 10g of menthol, dissolve it in an appropriate amount of ethanol, put it in the above-mentioned flask, stir at 50°C for 2 hours, let it stand at room temperature, filter the precipitate through a Buchner funnel under reduced pressure, scrape off the white solid, and dry it in vacuum at low temperature , crushed through an 80-mesh sieve to obtain the menthol cyclodextrin inclusion compound.

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Abstract

The invention discloses a disinfecting and sterilizing fomulation for vaginal mucosa, which comprises Cydiodini, diluent, crumbling agent, acid forming agent, and binding agent. The invention can be applied for effectively eradicate various microorganisms with stable physical and chemical property but no irritating action.

Description

technical field [0001] The invention relates to a series of preparations for vaginal disinfection and sterilization, in particular to cediiodine gynecological medicine. technical background [0002] Iodine has been widely used as a disinfectant for disinfection for more than a century. Iodine can be called a high-efficiency and low-toxic fungicide. It not only has a killing effect on various bacteria, aerobic bacteria and anaerobic bacteria, but also has a non-selective killing effect on various fungi and viruses. However, due to the activity of iodine element, it has poor chemical stability, is difficult to dissolve in water, has a strong odor, and is irritating to the skin and mucous membranes, so it cannot be directly used for mucous membrane disinfection. The above-mentioned shortcomings limit the application of iodine in medicine to varying degrees. [0003] Among gynecological diseases, the incidence of cervicitis, pelvic inflammatory disease, vaginitis, cervical ero...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61P15/02
Inventor 夏敏张同祥
Owner BEIJING WANHUI DOUBLE CRANE PHARMA
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