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Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract

A technology of polyglycolide lactide and plant extracts, applied in the field of nanomedicine, can solve problems such as insolubility, and achieve the effects of delayed release, low manufacturing cost and less loss

Inactive Publication Date: 2005-07-27
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor solubility of its main components such as fatty acids and lactones, and the resulting bioavailability problems have become more and more serious technical bottlenecks

Method used

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  • Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract
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  • Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Weigh 30mg and 150mg PLA of Maca, dissolved in 2ml of a mixture of dichloromethane and ethanol with a volume ratio of 5:1, add 8ml of 2.5% PVA aqueous solution by mass, and use probe-type ultrasonic ultrasound under ice bath for 5~ After 10 minutes, place in a shaker and shake overnight to remove dichloromethane and ethanol to obtain PLA nanoparticles with an average particle size of 250-350nm wrapped in maca.

Embodiment 2

[0028] Weigh 30mg and 150mg PLGA of Maca (L:G=50:50, L:G is the mass ratio of lactic acid (Lactide) and glycolic acid (Glycolide) monomers in the copolymer polylactide glycolide), and the volume ratio is 2ml of 5:1 mixture of dichloromethane and ethanol, dropwise add 8ml of 2.5% PVA aqueous solution by mass, and use probe-type ultrasonic ultrasound for 5-10 minutes in an ice bath. Place in a shaker and shake overnight to remove Dichloromethane and ethanol are used to obtain PLGA nanoparticles coated with maca with an average particle size of 250-350 nm.

Embodiment 3

[0030] Weigh 30mg and 150mg PLGA (L:G=25:75) of Maca, dissolved in 2ml of a mixture of dichloromethane and ethanol with a volume ratio of 5:1, and add dropwise 8ml of 2.5% PVA aqueous solution by mass, under ice bath Ultrasound with probe-type ultrasonic waves for 5-10 minutes, place in a shaker and shake overnight to remove dichloromethane and ethanol to obtain PLGA nanoparticles wrapped in maca with an average particle size of 250-350nm.

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Abstract

A polylactic PLA or poly-cyclic diester lactide PLGA nanometer particle for coating plant extract and its production are disclosed. PLA or PLGA nanometer particle is characterized by: coating plant extract as core matter with PLA or PLGA as shell membrane and forming nanometer spherical particle matter. The production is carried out by taking PLA or PLGA with good biological compatibility as carrier, taking polyvinyl alcohol PVA as emulsifier, and adopting solvent evolution method. Its advantages include low cost, simple process, to improve water soluble ability of main components, to improve plant extract adsorptive rate and biological utilizing rate.

Description

Technical field: [0001] The invention belongs to the field of nanomedicine, and specifically relates to packaging a variety of natural plant extracts into polylactic acid (PLA) or polyglycolide-lactide (PLGA) nanoparticles and a preparation method of the nanoparticles. Background technique: [0002] The plant extracts maca, kava, and ginger root oil are hardly water-soluble oils obtained by extracting the plant physiologically active ingredients from maca root, kava root and ginger root, respectively. Maca can increase physical strength, energetic, eliminate anxiety and improve sexual function. Kava is a good antidepressant, with sedative, hypnotic, anti-fungal, anti-thrombosis, anti-fatigue, weight loss, and muscle relaxation effects. The ginger root oil has the effects of enhancing and strengthening blood circulation, stimulating gastric juice secretion, stimulating the intestines, and promoting digestion. Recently, maca, kava, and ginger root oil have frequently appeared on th...

Claims

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Application Information

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IPC IPC(8): A61K47/34B29B9/12C08J3/12C08L67/00
Inventor 王柯敏谭蔚泓郑明彬何晓晓吴萍彭姣凤
Owner HUNAN UNIV
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