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Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis and therapy

A physical structure, polymer technology, applied in the field of heat-sensitive polymers, can solve the problem of not providing spherical particles, not providing magnetic particle encapsulation, etc.

Inactive Publication Date: 2005-08-24
MAGNAMEDICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process described therein provides neither clear magnetic particle encapsulation nor spherical particle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] 10 ml of 0.1 M Na-phosphate buffer, pH 7.2, containing 15% N-isopropyl recrystallized from n-hexane, 5% acrylamide and 0.6% N,N′-methylenebisacrylamide Acrylamide, and 2.5 ml of hydromagnetic colloid containing 2.2 mM Fe / ml (average particle size of 26 nm) produced according to Shinkai et al., Biocatalysis, Vol.5, 61, 1991 were mixed together and heated in an ultrasonic bath (250 W ) was exposed to ultrasound for 5 minutes while cooling with ice. Nitrogen was then introduced into the mixture for 15 minutes to remove excess oxygen. An aqueous solution consisting of 0.1 mg anti-p53-antibody (Roche Molecular Biochemicals), 0.05% human serum albumin, 2% inositol and 0.5% gelatin was added to the mixture. It was exposed to ultrasound for another 30 seconds while cooling with ice. Then, the aqueous phase was mixed with 2 ml of 30 oz. % ammonium persulfate solution (APS) and then suspended in 150 ml of trichlorethylene containing 1.5% of a mixture of 80% Span 85 and 20% Twe...

Embodiment 2

[0093] Cobalt-ferrite nanoparticles (CoFe 2 o 4 ) according to Sato et al., J. Magn. Magn. Mat., Vol.65, 252, 1987 from CoCl 2 and FeCl 3Produced and dispersed in water for 30 seconds in the presence of 0.75% polyacrylic acid (Mw: 5.500) with the aid of a high-power ultrasonic probe (manufactured by Dr. Hielscher, 80% amplitude), 5 ml of 21 nm particle size containing 1.9 mMFe / ml The colloid with 20ml has dissolved 15% N-isopropylacrylamide, 6% acrylamide, 1% acrylic acid, 0.5% Igepal 520 and 0.8% N, N'-methylenebisacrylamide of high purity and degassed of water mixed. The mixture was again exposed to ultrasonic waves using an ultrasonic probe for 1 minute while cooling with ice, and then placed in an ultrasonic bath for 30 minutes. After adding 2 ml of 40% APS, in a heat-controlled dispersing vessel (Ultra-Turrax LR 1000, IKA Werke) with introduction of nitrogen and under ice cooling, the mixture was aided by means of a disperser (Ultra-Turrax LR 1000, IKA Werke) under ic...

Embodiment 3

[0095] 7.5ml of 0.1M phosphate buffer with a pH value of 7.2, in which 20% N-isopropylacrylamide, 4% acrylamide, 1% N,N'-methylenebisacrylamide and 2.4% 2 - Hydroxy-methacrylate, purged with nitrogen for 20 minutes, then mixed with 2.5 ml of magnetite-ferrofluid (EMG 507, FerroTec, USA). The mixture was exposed to ultrasonic waves in an ultrasonic bath for 5 minutes while cooling with ice. Then 2 ml of 1% gelatin and insulin solution containing 0.1% HSA (Insuman(R) Basal, 100 IU / ml) were added. After adding 1.2ml of 35% APS solution to the aqueous phase, it was dispersed in 130ml of trichlorethylene containing 2.5% Span 60 and 1% Tween under stirring (1200rpm) and constant ice cooling and continuous nitrogen flow 80. After 20 seconds, 0.5 ml TEMED was added and the mixture was stirred at 10°C for 8 minutes. The reaction mixture was then allowed to stand at 15°C for 20 minutes to complete the reaction. Then, the magnetic phase is separated analogously to Example 1 and the re...

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Abstract

The invention relates to thermosensitive polymers which contain magnetic and / or metallic colloids and the physical structure of which can be modified by means of magnetic induction or by applying power, methods for the production thereof, and the use of such polymers for diagnostic and therapeutic purposes.

Description

technical field [0001] The present invention relates to thermosensitive polymers that can be heated by encapsulated magnetism and / or magnetic induction of metal colloids, thereby producing a change in their physical structure or shape. Among them, the shape change with heating is used to produce controllable drug depots (drug depots), contrast-enhancing media for NMR diagnostics, steerable microtools, as devices for occluding blood vessels and as controllable pore-forming substances in the production of thin films. [0002] The present invention relates to polymeric carriers of various geometries and particle sizes in which magnetic and / or metallic substances or magnetic and / or metallic core polymers containing colloids are polymerized, the polymeric carrier can be obtained by introducing heat or at high frequency, Selective heating under an alternating magnetic field results in a change in the physical structure and / or shape of the polymeric carrier, enabling said polymeric c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/545A61B5/055A61K9/52A61K41/00A61K47/34A61K47/42A61K47/48A61K49/00A61N2/10A61P35/00B01J20/28C08F2/44C08K9/04C08L33/26C08L101/00C09K3/00
CPCB82Y5/00A61K41/00A61K47/48861A61K47/6923A61P35/00A61K47/50
Inventor 德特勒夫·P·米勒-舒尔特
Owner MAGNAMEDICS
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