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Intraocular lenses with modified surface

A technology of intraocular lens and hydrophilic monomer, which is applied in the field of surface modification of polymeric materials, and can solve problems such as bad IOL turbidity and IOL turbidity

Inactive Publication Date: 2005-09-07
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Growth of this LEC on the surface of the IOL causes clouding of the undesirable IOL, necessitating removal or replacement of the IOL
Equally unfavorable is that the IOL produced by the silicone material will absorb the silicone oil used in the subsequent unrelated eye surgery and cause the clouding of the IOL

Method used

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  • Intraocular lenses with modified surface
  • Intraocular lenses with modified surface
  • Intraocular lenses with modified surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: Reactive hydrophilic N, the synthesis of N-dimethylacrylamide (DMA) and glycidyl methacrylate (GMA) copolymer

[0030]

[0031] Molecular weight = 99.13 Molecular weight = 142.16

[0032] Molecular formula = C 5 h 9 NO molecular formula = C 7 h 10 o 3

[0033] 48g, 0.48 mole 12g, 0.08 mole

[0034]

[0035] Distilled N,N-dimethylacrylamide (DMA, 48 grams, 0.48 moles), distilled glycidyl methacrylate (GMA, 12 grams, 0.08 moles), 2,2'-azobis Isobutyronitrile (AIBN, 0.096 g, 0.0006 mol) and toluene (600 ml) were added to a 1 liter reaction flask. The reaction vessel was equipped with a magnetic stirrer, cooler, temperature controller, and nitrogen inlet. Nitrogen was bubbled through the solution for 15 minutes to remove all dissolved oxygen. The reaction vial was then heated to 60°C for 20 hours under an insulated blanket of nitrogen. The reaction mixture was then slowly added to 6 liters of ether with good mechanical stirring. The reactive p...

Embodiment 2

[0038] Example 2: Synthesis of N, N-dimethylacrylamide (DMA), 1H, 1H, 5H-octafluoropentyl methacrylate (OFPMA) and water-soluble reactivity of glycidyl methacrylate (GMA) polymer

[0039]

[0040] Molecular weight = 99.13 Molecular weight = 300.15

[0041] Molecular weight = 142.16

[0042] Molecular formula = C 5 h 9 NO molecular formula = C 9 h 6 f 8 o 2

[0043] Molecular formula = C 7 h 10 o 3

[0044] 16g, 0.16 mole 1g, 0.003 mole

[0045] 4g, 0.028 mole

[0046]

[0047] Distilled N, N-dimethylacrylamide (DMA, 16 g, 0.16 moles), 1H, 1H, 5H-octafluoropentyl methacrylate (OFPMA, 1 g, 0.003 moles), distilled Glycidyl methacrylate (GMA, 4 g, 0.028 mol), 2,2'-azobisisobutyronitrile (AIBN, 0.03 g, 0.00018 mol) and toluene (300 ml) we...

Embodiment 2f

[0050] Example 2f: Synthesis of N, N-dimethylacrylamide (DMA), 1H, 1H, 5H-octafluoropentyl methacrylate (OFPMA), glycidyl methacrylate (GMA) and polyethylene glycol 1000 Reactive hydrophilic copolymer of monomethyl ether methacrylate (PEGMA)

[0051]

[0052] Molecular weight = 99.13 Molecular weight = 300.15

[0053]Molecular weight = 142.16

[0054] Molecular formula = C 5 h 9 NO molecular formula = C 9 h 6 f 8 o 2

[0055] Molecular formula = C 7 h 10 o 3

[0056]

[0057] Molecular weight = 1113.35

[0058] Molecular formula = C 51 h 100 o 25

[0059]

[0060] N,N-dimethylacrylamide (DMA, 8 grams, 0.08 moles), 1H, 1H, 5H-octafluoropentyl methacrylate (OFPMA, 1 gram, 0.003 moles) obtained by distillation were directly used (used as received)), distilled glycidyl methacrylate (GMA, 4 g, 0.028 mol), polyethylene glycol 1000 monomethyl ether methacrylate (PEGMA, 8 g, 0.007 mol), ...

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Abstract

Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers with catalyst functionality for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and / or reducing implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Description

technical field [0001] The present invention is primarily concerned with the surface modification of functional group-containing polymeric materials used in the production of medical devices. More specifically, the present invention relates to surface modification of intraocular lens implants formed from one or more functional group-containing materials using reactive hydrophilic polymers with catalyst functionality to reduce or eliminate Growth of epithelial cells on the surface of the lens. Background technique [0002] Ophthalmic medical devices in the form of intraocular lens (IOL) implants have been used since the 1940's as replacements for diseased or damaged natural lenses. Most of the time, an IOL is implanted in the eye at the same time as surgery to remove a diseased or damaged natural lens, such as a cataract. For decades, the preferred material for making these IOL implants was poly(methyl methacrylate) (PMMA), a hard, glass-like polymer. [0003] Softer, more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04A61F2/14A61F2/16A61F9/007A61L27/00A61L27/34
CPCA61L27/34C08J7/12A61L2400/18A61F2/16C08J2333/00
Inventor 小保罗·L.·瓦林特约瑟夫·A.·麦吉约瑟夫·C.·萨拉莫内
Owner BAUSCH & LOMB INC
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