Process for synthesizing dicreatine malic acid

A technology of dicreatine malate and creatine hydrochloride, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as difficulty in guaranteeing quality

Inactive Publication Date: 2005-10-19
江阴南极星生物制品有限公司
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  • Abstract
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Problems solved by technology

Due to the different impurities contained in the t...

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  • Process for synthesizing dicreatine malic acid
  • Process for synthesizing dicreatine malic acid
  • Process for synthesizing dicreatine malic acid

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Embodiment Construction

[0014] The present invention is a kind of method for synthesizing dicreatine malic acid, it adopts the salt exchange method to synthesize dicreatine malic acid, and its process step is carried out in three steps:

[0015] first step,

[0016] a) neutralize creatine with hydrochloric acid or sulfuric acid to generate creatine hydrochloride / creatine sulfate,

[0017] b) neutralizing malic acid with sodium hydroxide or calcium hydroxide to generate sodium malate / calcium malate;

[0018] The second step is to exchange creatine hydrochloride / creatine sulfate with sodium malate / calcium malate to generate dicreatine malate and sodium chloride / calcium chloride or sodium sulfate / calcium sulfate;

[0019] The third step is to use osmotic membrane technology to separate the contained inorganic salt sodium chloride / calcium chloride (sodium sulfate / calcium can be directly filtered and separated), and the filtrate obtained is concentrated and dehydrated, and dried to obtain the finished pr...

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Abstract

The present invention relates to salt exchange process of synthesizing dicreatine malic acid. The technological process includes the following three steps: neutralization reaction between creatine and hydrochloric acid or sulfuric acid to produce creatine hydrochloride or creatine sulfate, and neutralization reaction between malic acid and sodium hydroxide or calcium hydroxide to produce sodium salt or calcium salt of malic acid; exchange reaction between creatine hydrochloride or creatine sulfate and sodium salt or calcium salt of malic acid to produce dicreatine malic acid and sodium chloride/calcium chloride or sodium sulfate/calcium sulfate; and membrane separation to eliminate sodium chloride/calcium chloride and to obtain filtrate, concentration, dewatering and stoving to obtain dicreatine malic acid product with high quality and purity over 99.8 %.

Description

Technical field: [0001] The invention relates to a method for synthesizing dicreatine malic acid. It belongs to the field of organic chemical technology. Background technique: [0002] Dicreatine malic acid is a new type of health food raw material, which has a very broad market prospect in European and American countries. This product is imported in large quantities from China every year, but all of them are exported after being mixed with bis creatine and malic acid at a ratio of 2:1. Because the impurities contained in the two components are different, the quality is difficult to be guaranteed. Invention content: [0003] The object of the present invention is to overcome above-mentioned deficiency, a kind of method of producing the dicreatine malic acid of synthetic grade is provided. [0004] The object of the present invention is achieved like this: a kind of method of synthetic dicreatine malic acid, its processing step is carried out in three steps: [0005] fi...

Claims

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Application Information

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IPC IPC(8): C07C277/08C07C279/14
Inventor 钱华东叶峰黄再新
Owner 江阴南极星生物制品有限公司
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