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Fluorescent microball and process and application for preparing spray drying thereof

A technology of fluorescent microspheres and microspheres, applied in chemical instruments and methods, luminescent materials, pharmaceutical formulations, etc., can solve the problems of nanocomposite particles that do not have the ability to target tumors and biological toxicity, and achieve the particle size and shape of microspheres. Easy to control, good biocompatibility and high efficiency

Inactive Publication Date: 2005-11-09
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nanocomposite particles prepared by L.R. Hirsch et al. do not have the function of targeting tumors
Moreover, exposed metal nanoparticles may release metal ions in the body, causing toxicity to organisms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Appropriate concentration of near-infrared fluorescent quantum dots CdTe, nano-Fe 3 o 4 And bovine serum albumin (BSA) aqueous solution is mixed, as the precursor solution of spray drying. In the precursor solution, the solute concentration is 30 wt%. When spray drying, the feed rate is 5mL min -1 , the inlet air temperature is 60°C, the outlet air temperature is 50±2°C, and the rotation speed of the atomizing disc is 20000r·min -1 . The carrier gas is air. The obtained powder was further dried at 120 °C to denature the BSA.

[0034] As a result, a dry powder sample was obtained, the microscopic appearance was spherical, and the particle size was 1-3 μm. When the BSA concentration in the precursor solution was 1 wt%, what was obtained was a regular microsphere with a smooth surface; the concentration of BSA in the precursor solution When it is 20wt%, there are depressions and holes on the surface of some microspheres. All microspheres are insoluble in water and h...

Embodiment 2

[0036] Appropriate concentration of near-infrared fluorescent quantum dots CdTe, nano-Fe 3 o 4 And bovine serum albumin (BSA) aqueous solution is mixed, as the precursor solution of spray drying. In this precursor solution, the solute concentration is 60wt%, and when spray drying, the feed rate is 0.5mL·min -1 , the air inlet temperature is 60°C, the air outlet temperature is 50±2°C, and the rotation speed of the atomizing disc is 20000r·min -1 . The carrier gas is air. The obtained powder was further dried at 120 °C to denature the BSA.

[0037] As a result, spherical particles with a particle size of 5-20 μm were obtained, and their optical properties, magnetic properties and water solubility were similar to those of the product in Example 1.

Embodiment 3

[0039] Appropriate concentration of near-infrared fluorescent quantum dots CdTe, nano-Fe 3 o 4 And bovine serum albumin (BSA) aqueous solution is mixed, as the precursor solution of spray drying. In this precursor solution, the solute concentration is 0.1wt%, and when spray drying, the feed rate is 100mL·min -1 , the air inlet temperature is 200°C, and the rotation speed of the atomizing disc is 20000r·min -1 . The carrier gas is air.

[0040] As a result, the particles with a particle size mainly distributed in the range of 800nm ​​to 3μm were obtained, and individual particles were only 500nm. Most of the microspheres have depressions and holes on the surface, and the microspheres are insoluble in water. Its optical properties, magnetic properties and water solubility etc. are also similar to the product of Example 1.

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Abstract

A fluorescent microsphere for treating tumor and biomedical marking is prepared from near-infrared fluorescent substance, magnetic nanoparticles, gold nanoparticles, anticancer medicine and high-molecular material through spray drying to include the first four components in the high-molecular microsphere, and linking the biologic moleculae with recognizing function to the surface of microsphere.

Description

technical field [0001] The present invention relates to a fluorescent microsphere and a preparation method thereof, in particular to a method for preparing magnetic near-infrared fluorescent microspheres and gold microspheres by a spray drying method, and using the obtained fluorescent microspheres for biomedicine It belongs to the intersection field of nanotechnology, chemical engineering and biomedicine in labeling and tracing, disease diagnosis and treatment. Background technique [0002] Fluorescent labeling and tracing technology is a pillar technology in the field of biology. In addition to traditional organic fluorescent dye molecules and gold nanoparticles, substances that can emit fluorescence include semiconductor quantum dot nanoparticles, and rare earth element compounds. They can not only be used as probes for fluorescent labeling and tracking, but also be used in the treatment of diseases, especially tumors. [0003] Since 1998, Nie's research group and Alivis...

Claims

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Application Information

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IPC IPC(8): C09K11/00
Inventor 储茂泉金平
Owner TONGJI UNIV
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