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Dispersion tablet of nisoldipine and preparation method

A technology of nisoldipine and dispersible tablets, applied in the field of nisoldipine dispersible tablets and its preparation, can solve the problems of unfavorable drug absorption and slow decomposition speed, and achieve the effect of high bioavailability and fast absorption

Inactive Publication Date: 2005-11-16
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently used nisoldipine dosage forms are ordinary compressed tablets, sustained-release tablets and sustained-release capsules, which decompose slowly in the stomach, which is not conducive to the absorption of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: present embodiment prepares 1000 nisoldipine dispersible tablets, use following raw material:

[0009] Nisoldipine 5g Lactose 40g

[0010] Microcrystalline Cellulose 45g L-Hydroxypropyl Cellulose 10g

[0011] Sodium Carboxymethyl Starch 5g Magnesium Stearate 1g

[0012] Polyethylene glycol 6000 5g Starch 19g

[0013] After the above raw materials are passed through 80 mesh sieves, they are weighed according to the above-mentioned amount, then the prescription amount of nisoldipine, lactose, L-hydroxypropyl cellulose, polyethylene glycol 6000 and 20g microcrystalline cellulose are mixed evenly, Use 5% PVP aqueous solution to make soft materials, then pass through a 20-mesh sieve to granulate, then dry and granulate, then fully mix with 20g microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate in prescription quantities, and use It can be obtained by pressing a tablet machine.

Embodiment 2

[0014] Embodiment 2: present embodiment prepares 1000 nisoldipine dispersible tablets, uses following raw material:

[0015] Nisoldipine 8g Starch 50g

[0016] Mannitol 40g Cross-linked polyvinylpyrrolidone 15g

[0017] Sodium carboxymethyl starch 8g Micropowder silica gel 2g

[0018] Polyethylene glycol 6000 5g Starch 15g

[0019] The preparation method is the same as in Example 1.

Embodiment 3

[0020] Embodiment 3: present embodiment prepares 1000 nisoldipine dispersible tablets, use following raw material:

[0021] Nisoldipine 10g Dextrin 35g

[0022] Sorbitol 45g Calcium Ammonium Alginate 20g

[0023] Sodium carboxymethyl starch 10g Micropowder silica gel 3g

[0024] Polyethylene glycol 6000 7g Starch 16g

[0025] The preparation method is the same as in Example 1.

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PUM

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Abstract

A dispersing tablet of nisoldipine is proportionally prepared from nisoldipine, filler, adhesive and disintegrant. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to a nisoldipine dispersible tablet and a preparation method thereof. technical background [0002] Cardiovascular and cerebrovascular diseases are one of the diseases with the highest morbidity and mortality in the world today. They are the leading cause of death and the number one killer of health. The incidence of cardiovascular system diseases in my country is basically the same as that in the world, showing an upward trend year by year. From the 7th cause of death in the 1960s to the 1st, 3 million people die from cardiovascular and cerebrovascular diseases every year, and 10 million people become disabled due to cardiovascular and cerebrovascular diseases. Almost every cardiovascular and cerebrovascular patient has clinical symptoms of elevated blood pressure and needs antihypertensive treatment. The market for antihypertensive drugs is huge. Nisoldipine in...

Claims

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Application Information

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IPC IPC(8): A61K31/4422
Inventor 谢元德马越峰朱旭雷苏春胜陈世友陈春
Owner 浙江南洋药业有限公司
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