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Baicalin soft capsule and preparation method thereof

A technology of soft capsules and baicalin, which is applied in the field of baicalin soft capsules and its preparation, and can solve the problems of low bioavailability and poor stability

Inactive Publication Date: 2005-11-23
宛六一 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to overcome the problems of poor stability and low bioavailability of existing baicalin oral preparations, and increases the stability of the product by preparing baicalin soft capsules whose contents are water-soluble, and changes the dissolution of baicalin oral preparations The shortcomings of low degree and bioavailability improve the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] PEG400 300g

[0012] Baicalin 300g

[0013] Triethanolamine 30g

[0014] Hydroxypropyl-β-cyclodextrin 20g

[0015] Glycerin 40g

[0016] Granulation 1000 grains

[0017] Capsule shell glue formula:

[0018] Gelatin: Glycerin: Water = 1:0.6:0.7

[0019] Consideration factors

[0020] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

Embodiment 2

[0022] PEG400 475g

[0023] Baicalin 140g

[0024] Meglumine 15g

[0025] Pluronic F-68 15g

[0026] Glycerin 55g

[0027] Granulation 1000 grains

[0028] Capsule shell glue formula:

[0029] Gelatin: Sorbitol: Water = 1:0.5:0.8

[0030] Consideration factors

[0031] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

Embodiment 3

[0033] PEG400 250g

[0034] Baicalin 400g

[0035] Monoethanolamine 50g

[0036] Propylene glycol 100g

[0037] Granulation 1000 grains

[0038] Capsule shell glue formula:

[0039] Gelatin: Glycerin: Water = 1:0.4:0.9

[0040] Consideration factors

[0041] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

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PUM

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Abstract

The invention relates to a baicalin soft capsule and preparation process, the content of the soft capsule is water-soluble, and contains baicailin and other auxiliary materials. The soft capsule is prepared through mixing the baicailin with the auxiliary materials and dissolving.

Description

technical field [0001] The invention relates to a baicalin soft capsule and a preparation method thereof. By selecting the composition, the soft capsule whose content is a transparent solution is prepared. Background technique [0002] Baicalin (Baicailin, Bai) is a flavonoid compound extracted from the Chinese medicinal material Scutellaria baicalensis georgi, which has a wide range of pharmacological effects. It has obvious inhibitory effect and can significantly inhibit hepatitis B virus surface antigen, e antigen and core antigen and DNA replication. In recent years, with the deepening of the development of new uses of traditional Chinese medicine, it has been found that baicalin also has the functions of anti-lipid peroxidation, inhibition of aldose reductase (AR), prevention and treatment of chronic complications such as diabetic peripheral neuropathy and diabetic nephropathy. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048
Inventor 宛六一
Owner 宛六一