Chromatogram arrangement of supercritical fluid imitation moving bed with four subareas

Abstract

This invention discloses a quartering color spectrum device, which comprises 4~48 filling columns, wherein the exit end of the front column is connected with the entrance end of next rear column through the voltage regulator, and the exit end of the last column is connected with the entrance end of the first column; the entrance end of each column is connected with the mobile phase inlet orifice and the injection port, while the exit end of each column is connected with the extraction pipe, relict pipe and the mobile phase outlet orifice; the exit end of the extraction pipe, relict pipe and the mobile phase outlet orifice are connected with the cyclonic separator individually; the mobile phase is the supercritical fluid. The device can apply pressure gradient operator schema and the modifier gradient operator schema. Meanwhile, it uses the supercritical carbon dioxide fluid as the mobile phase, and uses the chirality fixed phase as the filler of the filling column.

Description

technical field [0001] The invention relates to an industrial preparation chromatographic separation device which contains an adsorbent for treating supercritical fluid, in particular to a four-part supercritical fluid simulated moving bed chromatographic device for splitting chiral drug racemate. Background technique [0002] The US Food and Drug Administration (FDA) issued guidelines for chiral drugs in March 1992, proposing a strategy for developing single-enantiomer drugs with less toxic side effects. Therefore, the development of racemic chiral drugs into high value-added single enantiomer drugs has become an unavoidable and urgently resolved major issue in the global pharmaceutical industry. [0003] In recent years, with the development of preparative chromatography technology and the commercialization of chiral stationary phases suitable for preparative use, preparative liquid chromatography has opened up a new way for the acquisition of single enantiomer drugs. Pha...

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Problems solved by technology

Although liquid phase simulated moving bed chromatography has shown such excellent performance, it still needs to consume 439 liters of organic solvent mobile phase to produce per kilogram of product, which means that the cost of solvent consumed to produce one ton of single enantiomer drug will be as high as nearly one hundred Ten thousand yuan, and at the same time, it will bring environmental problems that cannot be ignored

[0006] In addition, when the existing liquid-phase simulated moving bed chromatography is scaled up on an industrial scale, it involves the transportation of a large amount of organic solvents and high-pressure fluids, and these organic solvents are often flammable and explosive. Therefore, pumps, valves, instruments, The selection of key equipment such as electrical equipment and the overall design of the process workshop will put forward very strict safety requirements, which will increase equipment investment and operating costs

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