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Dispersed tablet sof tannic matrine and their preparing method

A technology of tannic acid Sophora flavescens and preparation process, which can be applied to medical preparations containing active ingredients, organic active ingredients, resistance to vector-borne diseases, etc., can solve problems such as difficulty in taking infants and young children, difficulty in swallowing tablets, and poor compliance, etc. To achieve the effect of improving compliance and significant curative effect

Active Publication Date: 2005-12-28
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical application process, because the tablets with a diameter of about 7mm are difficult to swallow, infants and young children have poor compliance when taking them, which limits the wide application of this product to a certain extent.
In addition, because of the bitter taste of tannic acid and matrine, if it is directly prepared into dispersible tablets and taken after dispersing, there is also the problem of difficulty in taking it for infants and young children.

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0022] Example of the present invention: Take the preparation of 1000 tablets, each weighing about 130mg-140mg (10mg containing matrine) as an example:

[0023] 1. Pretreatment of powder: Take 85g of the raw material of matrine tannin and granulate with PVP ethanol solution. The appropriate dosage is about 40ml / 100g powder to make 100 mesh particles.

[0024] 2. Granule treatment: In order to reduce the wall sticking phenomenon during the coating process and increase the antistatic ability of the powder, 0.85g of micronized silica gel is added as a glidant before coating.

[0025] 3. Selection of coating solution: According to the characteristics of matrine tannin dissolved in the acidic conditions of the gastric juice after oral administration, the total alkaloids and tannins of Sophora flavescens are freed to play a pharmacological effect together, the present invention mainly adopts the gastric-soluble type As the coating material, 8.6 g of polyacrylic resin (No. IV) was select...

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PUM

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Abstract

A dispersing tablet of matrine tannate for treating the infantile diarrhea, bacterial dysentery and enteritis is prepared from matrine tannate, polyvinyl pyrrolidone, polyacrylic resin, cross-linked povidone and sweetening agent.

Description

Technical field: [0001] The invention relates to a medicine dispersible tablet and its preparation process. technical background: [0002] The main component of tannin matrine tablets is tannin matrine, which is the total alkaloids of matrine extracted from the roots and rhizomes of the leguminous plant Sophora flavescens Ait. ., Green bran poplar Rhus potaninii Maxim., or red bran poplar Rhus punjabensis Stew. Var. sinica (Diels) Rehd. A weak base salt of organic tannic acid synthesized by the reaction of tannins. After oral administration, it dissolves under the acidic conditions of gastric juice, freeing the total alkaloids and tannins of Sophora flavescens to exert pharmacological effects together. The original dosage form is ordinary tablets, which are clinically used for bacillary dysentery and enteritis, etc., with definite curative effect, especially for children with diarrhea. However, in the process of clinical application, because tablets with a diameter of about 7mm a...

Claims

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Application Information

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IPC IPC(8): A61K31/7028
CPCY02A50/30
Inventor 冉骥
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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