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Chinese medicinal formulation containing scutellarin and its preparing process

A technology of scutellarin and traditional Chinese medicine preparation, which is applied in the field of preparation and preparation of traditional Chinese medicine microspheres containing scutellarin, to achieve the effects of promoting absorption, stable quality, good drug loading and encapsulation efficiency

Inactive Publication Date: 2006-02-08
GEJIU BIO PHARMA YUNNAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on this aspect at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of microspheres by single coacervation method

[0041] Disperse the drug in 5% gelatin solution to form a suspension, add 10% acetic acid solution at 50 degrees Celsius to adjust the pH to 3.5-3.8, add 60% sodium sulfate solution to form coagulation vesicles, and then add an equivalent of 3 times Measure the 61.5% sodium sulfate dilution of the total volume to form a sedimentation capsule, solidify with a 37% formaldehyde solution (adjust the pH to 8-9 with 20% NaOH) below 15 degrees Celsius to form a solidification capsule, and finally wash with water until there is no formaldehyde to form Microspheres. The whole process requires constant stirring.

Embodiment 2

[0042] Example 2 Preparation of microspheres by spray drying method.

[0043] Microspheres were prepared by spray drying method. Dissolving scutellarin in 10% disodium hydrogen phosphate solution, pouring directly into the capsule material solution, adding an absorption accelerator and a plasticizer, mixing evenly, and spray drying to obtain microspheres. The single factor investigation method takes the appearance (roundness), particle size (particle size, particle size difference) and drug loading of the microspheres as indicators.

Embodiment 3

[0045] The drug is dispersed in 5% gelatin solution to form a suspension, which is input into a spray dryer through a peristaltic pump, nitrogen is used as a hot air flow, and the suspension is evaporated to obtain microspheres.

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Abstract

The invention relates to a pharmaceutical composition containing Breviscapine through nasal cavity administration, wherein the preparation comprises 5-40 wt% of Breviscapine and 60-95% of medicinal auxiliary materials containing coagulating agent, emulsifying agent, plasticizing agent, flow aid and absorption promoting agent.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method, in particular to a traditional Chinese medicine microsphere preparation containing scutellarin and a preparation method. Background technique [0002] Erigron breviscapus (vanioot) Hand Mazz is a plant of the family Asteraceae. Its nature and flavor are warm and pungent, and has the effects of promoting blood circulation and removing blood stasis, relieving exterior pain, dispelling cold and dehumidification, eliminating accumulation and detoxification. It is suitable for stroke sequelae, coronary heart disease, angina pectoris, etc., and has a unique curative effect on the treatment of embolic cerebrovascular diseases and hemorrhagic cerebrovascular sequelae. Its extract contains a variety of flavonoid active ingredients. [0003] Since the 1970s, breviscapine preparations made of its total flavonoids, such as breviscapine injection, breviscapine injection,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K31/7048A61K9/16A61K9/12A61P9/10A61P7/02
Inventor 张宁冉立新冯怡管文俊晋仲民
Owner GEJIU BIO PHARMA YUNNAN