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Use of sophoridine oxide in preparing anticancer medicine

A technology of oxysophoridine and uses, which is applied in the directions of antitumor drugs, pharmaceutical formulations, sugar-coated pills, etc., can solve the problem that the use of oxysophoridine has not yet been reported, and achieves obvious and stable anti-cancer effect, increased appetite, immunity force-enhancing effect

Inactive Publication Date: 2006-03-01
刘平
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The use of oxysophoridine in anticancer has not been reported yet

Method used

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  • Use of sophoridine oxide in preparing anticancer medicine
  • Use of sophoridine oxide in preparing anticancer medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0013] Experimental example 1 Toxicity test of oxysophoridine

[0014] Acute toxicity test with mice to determine oxysophoridine LD 50 It is 560mg / kg. Then carry out the chronic toxicity test according to the following method.

[0015] The experimental animals were white mice and nude mice provided by the Institute of Zoology, Chinese Academy of Sciences, and they were divided into two groups, with the white mice being a large group and the nude mice being a large group. Each group is divided into small doses (LD 10 ), medium dose (LD 15 ), high dose (LD 25 ), blank control four groups. 20 rats per group. Calculate the dosage of each mouse according to the actual body weight and the proportion of the drug used in the group. Gavage, once every 3 days, for 6 months, stop the drug for 15 days, observe the delayed toxicity .

[0016] Observation indicators:

[0017] Observe the general state of the animals before and after the administration, eating, drinking, feces, growth and develo...

experiment example 2

[0035] Experimental Example 2 Pharmacodynamic test of oxysophoridine against malignant tumors

[0036] The transplantation animal tumor experiment was carried out in accordance with the "in vivo screening procedures for antitumor drugs" formulated by the China National Cancer Conference in 1983.

[0037] (1) Manufacturing of transplantable animal tumor models

[0038] 1. Tumor strains: Three human cancer xenografts prepared by the Chinese Academy of Medical Sciences were selected. The tumor strains were MX1 (breast cancer), LX1 (lung cancer), and CX1 (rectal cancer).

[0039] 2. Animals: Two purebred animals, white mice and nude mice, provided by the Institute of Zoology, Chinese Academy of Sciences, are selected for use after quarantine.

[0040] 3. Transplantation: Cut the three tumor strains into 3mm 3 The large and small pieces were injected into the armpits of the transplanted animals' forelimbs by injection, which lasted 10-12 days. When the tumors were growing vigorously, t...

experiment example 3

[0056] Experimental example 3 Case record of oxysophoridine clinical treatment of cancer

[0057] Case 1 Female, 71 years old, living in Inner Mongolia, suffering from breast cancer has metastasized, has lost the indications for surgery, and has very poor adaptability to chemotherapy. She was changed to oral therapy with oxysophoridine capsules, 0.3 grams each time, 3 times a day, continuous medication At 6 months, the local mass disappeared, and the blood test indicators were all within the normal range.

[0058] Case 2 Female, 52 years old, living in Beijing, suffering from cervical cancer has been extensively metastasized. She was hospitalized in two tertiary hospitals in Beijing. She was considered to have lost the indications for surgery, so she changed to oxysophoridine capsules for oral treatment. 0.3 g, 3 times a day, after 3 months of continuous medication, the local lumps shrank, appetite increased, and the general condition improved significantly.

[0059] Case 3 Female...

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Abstract

The present invention relates to the use of sophoridine oxide in preparing medicine for treating adenocarcinomas, including breast carcinoma, lung carcinoma, intestinal cancer and other cancer on gland. Sophoridine oxide in effective treating amount and pharmaceutically acceptable supplementary material are used in preparing the medicine in the forms one freeze dried powder for injection, soft capsule, dripping pill, coated tablet, etc. Sophoridine oxide has anticancer activity higher than that of sophoridine and toxic side effect less than that of sophoridine.

Description

Technical field [0001] The invention relates to the use of oxysophoridine in pharmacy, in particular to the preparation of drugs for treating malignant tumors, especially adenocarcinoma. Background technique [0002] Oxy sophoridine (Oxy sophoridine) is a nitrogen-containing heterocycle—quinolizidine compound with a molecular weight of 264 and a molecular formula of C 15 H 24 N 2 O 2 , Normally it is white crystalline powder with extremely bitter taste. It is known that oxysophoridine has antibacterial, antiviral, antimycoplasma and antichlamydia effects, and is widely used in anti-inflammatory and anti-infective aspects. [0003] Sophocarine, an alkaloid of the same family as Sophocarine, has a molecular weight of 248 and a molecular formula of C 15 H 24 N 2 O. Sophoridine has anti-inflammatory and anti-infective effects similar to oxysophoridine. Sophoridine has also been reported to have anticancer activity. Chinese Patent No. 93100881.6 "Use of Sophoridine" and Patent Applica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/28A61K9/48A61K9/52A61K9/19A61P35/00
Inventor 刘平于丽华
Owner 刘平
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