Solid and liquid attapulgite prepn for treating digestive tract diseases

A technology of attapulgite and solution, which is applied to the digestive system, pill delivery, block delivery, etc., can solve problems such as inability to meet clinical requirements, and achieve the effects of remarkable curative effect, simple process and low product cost.

Inactive Publication Date: 2006-03-01
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the preparations of natural ores on the market on

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] 1. Prescription and process of attapulgite granules and capsules:

[0033] prescription:

[0034] Attapulgite 300-1200mg

[0035] Appropriate amount of HPMC-K4M

[0036] Appropriate amount of water or ethanol

[0037] Appropriate amount of talcum powder or magnesium stearate

[0038] Process: Dry the attapulgite at 80°C, cool, sieve, and heat at 200°C for 0.5-2 hours for later use. Take attapulgite, use 2% HPMC-K4M as a binder to make soft material, granulate with a 40 mesh sieve, granulate, dry at 60°C for 2 hours, add lubricant, and pack the granules into bags. Each bag contains attapulgite 300 -1200mg. Capsules: Pack the obtained granules into No. 1 capsules, each containing 300-600 mg of attapulgite.

[0039] 2. Attapulgite tablet prescription and process:

[0040] prescription:

[0041] Attapulgite 300-1100mg

[0042] Carbopol-971P 1-25%

[0043] Appropriate amount of water or ethanol

[0044] Sodium carboxymethyl starch appropriate amount

[0045] Appr...

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Abstract

The present invention belongs to the field of medicine preparation technology, and natural attapulgite is used as the active component for treating acute and chronic diarrhea, enteritis and other digestive tract diseases. Attapulgite as one natural mineral is hard, great in specific surface area and hard to process. The present invention prepares attapulgite capsule, tablet, granule and gel through solving relevant technological problems in tabletting, encapsulating, etc. and the preparations have the physiological activity maintained.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations. 2. Background technology: [0002] The active ingredient of the invention is natural attapulgite powder in my country, which is a safe natural ore powder produced in China and has strong adsorption performance. Attapulgite has been used in the healing treatment of wounds in China. However, attapulgite has strong water absorption and hard texture, and its physiological activity decreases after absorbing water, so it has caused great difficulties to the solid preparation and liquid processing technology. The capsule shell will lose water and become brittle and brittle due to the water absorbed by the attapulgite; during tablet processing, the attapulgite is hard and elastic, making it difficult to form. The liquid preparation will cause the attapulgite to absorb a large amount of water, and lose its adsorption performance, thereby losing its physiological activity. Therefor...

Claims

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Application Information

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IPC IPC(8): A61K35/02A61K33/06A61K9/16A61K9/20A61K9/48A61P1/12A61K33/12
Inventor 胡一桥王贺童春晖
Owner NANJING UNIV
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