Preparation method and application of stem type traditional Chinese medicinal material granules

A technology of Chinese medicinal materials and vines, which is applied in the field of preparation of vines and woods without decoction. It can solve the problems of difficult dissolution and release of active ingredients, incomplete extraction of active ingredients, and destruction of active ingredients of medicinal materials, etc., to increase solvent penetration. Power, enhance bioavailability, improve the effect of therapeutic effect

Inactive Publication Date: 2015-12-23
HENAN XINGZHI PATENT SERVICE CO LTD
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  • Description
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AI Technical Summary

Problems solved by technology

Due to the complex chemical composition of vine-like Chinese medicinal materials, traditional extraction methods will destroy the active ingredients in the medicinal materials
The specific surface area of ​​traditional vine and wood herbal pieces is small, and the active ingredients are not easy to dissolve and release. Using traditional extraction methods will lead to incomplete extraction of active ingredients, low extraction yield, and long extraction time

Method used

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  • Preparation method and application of stem type traditional Chinese medicinal material granules
  • Preparation method and application of stem type traditional Chinese medicinal material granules

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preparation example Construction

[0026] A preparation method of vine-like Chinese medicinal material free decoction, comprising the following steps:

[0027] 1) Pick up rattan-like Chinese medicinal materials, remove impurities, dry, pulverize, and pass through a 30-40 mesh sieve to obtain rattan-like Chinese medicinal materials coarse powder;

[0028] 2) Put the rattan-like Chinese medicinal material coarse powder obtained in step 1) into a steam explosion machine, and inject high-pressure steam for steam explosion to obtain a steam-exploded wall-breaking powder of Chinese medicinal material;

[0029] 3) Add 10-20 times the volume of water to the steam-exploded wall-breaking powder of Chinese medicinal materials obtained in step 2), soak for 60-120 minutes at 35-55°C, and then add 0.1%~ 0.8% cellulase is used for enzymatic hydrolysis and ultrasonic-assisted treatment to obtain the extract;

[0030] 4) The extract obtained in step 3) is subjected to microfiltration treatment, then enters the concentration eq...

Embodiment 1

[0040]Taking Saponaria thorn as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0041] 1) Pick up the saponins and remove impurities, dry, pulverize, and pass through a 30-40 mesh sieve to obtain the saponins coarse powder;

[0042] 2) Put the saponin thorn coarse powder obtained in step 1) into a steam explosion machine, inject high-pressure steam for steam explosion, the pressure is 0.5 MPa, and the maintenance time is 5 minutes, and the saponin thorn wall breaking powder is obtained;

[0043] 3) Add 10 times the volume of water to the saponin root steam-exploded wall powder obtained in step 2), soak for 60 minutes at 35°C, and then add cellulase ( Enzyme activity 1×10 4 U / g) for enzymolysis, the enzymolysis temperature is 35°C, the pH is 4.0, and the enzymolysis time is 70min. At the same time, ultrasonic assisted treatment is carried out, the ultrasonic frequency is 18kHz, the power is 300W, and the time is 15min. Repe...

Embodiment 2

[0047] Taking Mutong as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0048] 1) Pick up Akebia to remove impurities, dry, crush, and pass through a 30-40 mesh sieve to obtain Akebia coarse powder;

[0049] 2) Put the akebia coarse powder obtained in step 1) into the steam explosion machine, and inject high-pressure steam for steam explosion, the pressure is 0.6MPa, and the maintenance time is 6 minutes, and the akebia wall breaking powder is obtained;

[0050] 3) Add 12 times the volume of water to the wood steam blasting wall powder obtained in step 2), soak for 70 minutes at 40°C, and then add 0.3% cellulase (enzyme activity) of the wood steam blasting wall powder weight 1×10 4 U / g) for enzymolysis, the enzymolysis temperature is 40°C, the pH is 4.5, and the enzymolysis time is 80min. At the same time, the ultrasonic assisted treatment is carried out, the ultrasonic frequency is 20kHz, the power is 350W, and the time i...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation and particularly relates to a preparation method and an application of stem type traditional Chinese medicinal material granules. According to the preparation method, stem type traditional Chinese medicinal materials are subjected to steam explosion wall breaking treatment, effective ingredients are extracted with an ultrasonic-assisted enzyme method, then ceramic membrane microfiltration treatment is adopted, and finally, the stem type traditional Chinese medicinal material granules are obtained through concentration, drying and nano-crushing. Traditional Chinese medicine compound preparations containing the stem type traditional Chinese medicinal materials or stem type traditional Chinese medicinal material extracts can be prepared from the granules. The problems that the utilization rate of raw materials is low, effective components are extracted incompletely, the extraction efficiency is low and the like when traditional Chinese medicinal materials are extracted with conventional methods are solved, the whole technological process is simple to control and environment-friendly, all technological steps have a synergistic effect, so that the preparation method is higher in extraction efficiency, the effective ingredients are effectively protected, and the availability of the stem type traditional Chinese medicinal materials is increased.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a preparation method and application of rattan-like traditional Chinese medicinal material free decoction. Background technique [0002] Traditional Chinese medicine is a unique medicine of traditional Chinese medicine, with a long history and rich resources. The ingredients of traditional Chinese medicine are complex and diverse. If the appropriate extraction, concentration, preparation process and scientific and strict process operation parameters are not selected during the preparation of traditional Chinese medicine preparations, the active ingredients will be incompletely extracted or even destroyed, thereby affecting the efficacy of the medicine. The traditional dosage forms of traditional Chinese medicine include pills, powders, ointments, liquors, etc., but most of the traditional dosage forms have shortcomings such as larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K36/483A61K36/185A61K36/486A61K36/736A61K36/835A61K135/00
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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