Slow releasing injection containing anti-mitosis medicine

Abstract

The slow releasing injection containing antimiotic medicine belongs to the field of slow releasing anticancer medicine technology. The injection includes the components of anticancer medicine, slow releasing supplementary material, suspending agent and / or solvent. The anticancer medicine includes cytochalasin, colchicines, beta-naphthol, acodazole, giracodazole, nocodazole or other antimiotic medicine; the slow releasing supplementary material is polylactic acid, glycolic acid-hydroxyacetic acid copolymer, EVA, polifeprosan or their composition; the suspending agent is carboxymethyl cellulose, mannitol, etc.; the solvent is selected from distilled water, injection water, anhydrous alcohol, etc. The slow releasing anticancer injection may be injected in different modes and has reduced systemic toxic reaction, raised local medicine concentration and raised treating effect.

Description

(1) Technical field [0001] The invention relates to a sustained-release injection containing antimitotic drugs, belonging to the technical field of medicines. (2) Background technology [0002] Antimitotic drugs, as commonly used chemotherapeutic drugs, have been widely used in the treatment of various malignant tumors, and have achieved relatively obvious effects. However, further studies have found that inappropriate drug administration often leads to the generation of tolerance, which eventually leads to the failure of treatment. Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of brain tumors in ra...

AI Technical Summary

Problems solved by technology

However, further studies have found that inappropriate drug administration often leads to the development of tolerance, which eventually leads to the failure of treatment

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of brain tumors in rats", "Journal of Surgical Oncology", 1998, 69, pages 76-82 (Kong Q et al., J Surg Oncol.1998 Oct; 69 (2) :76-82), simply increasing the dosage is limited by systemic reactions

Drug implantation may solve the problem of drug concentration to some extent. However, the operation of drug implantation is more complicated and traumatic. In addition to easily causing various complications such as bleeding, infection, and decreased immunity, it can also cause or accelerate tumor spread and metastasis