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Disperese torasemide tablet and its prepn and application

A technology of torasemide and dispersible tablets, which is applied in the field of medicine and can solve problems such as the influence of drug absorption, slow disintegration speed, and inconvenience in taking medicine

Inactive Publication Date: 2006-05-17
周卓和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Capsules usually have the disadvantages of slow disintegration speed, low dissolution rate, and certain influence on drug absorption. At the same time, for patients who are not easy to swallow, capsules also have the disadvantage of inconvenient medication.

Method used

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  • Disperese torasemide tablet and its prepn and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Prescription composition:

[0028] Torsemide 20g

[0029] Microcrystalline Cellulose 50g

[0030] Carboxymethyl Starch Sodium 6g

[0031] Hypromellose 15g

[0032] Stevia 6g

[0033] Talc powder 3g

[0034] 70% ethanol appropriate amount

[0035] Makes 1000 pieces

[0036] (2) Preparation process

[0037] 1. Grind the torasemide and auxiliary materials through a 100-mesh sieve, and set aside;

[0038] 2. Accurately weigh the raw and auxiliary materials according to the prescription quantity, first mix microcrystalline cellulose, hydroxypropyl cellulose, and stevioside auxiliary materials evenly, and then mix with the main drug, add 70% ethanol to make a soft material, and granulate with a 20-mesh sieve , dried at 55°C, sieved with a 60-mesh sieve, added sodium starch glycolate and talcum powder and mixed evenly;

[0039] 3. Measure the particle content and calculate the tablet weight;

[0040] 4. Tablet, ready to use.

Embodiment 2

[0042] (1) Prescription composition:

[0043] Torsemide 10g

[0044] Microcrystalline Cellulose 60g

[0045] Carboxymethyl Starch Sodium 6g

[0046] Hypromellose 15g

[0047] Stevia 6g

[0048] Talc powder 3g

[0049] 70% ethanol appropriate amount

[0050] Makes 1000 pieces

[0051] (2) Preparation process

[0052] 1. Grind the torasemide and auxiliary materials through a 100-mesh sieve, and set aside;

[0053] 2. Accurately weigh the raw and auxiliary materials according to the prescription quantity, first mix microcrystalline cellulose, hydroxypropyl cellulose, and stevioside auxiliary materials evenly, and then mix with the main drug, add 70% ethanol to make a soft material, and granulate with a 20-mesh sieve , dried at 55°C, sieved with a 60-mesh sieve, added sodium starch glycolate and talcum powder and mixed evenly;

[0054] 3. Measure the particle content and calculate the tablet weight;

[0055] 4. Tablet, ready to use.

Embodiment 3

[0057] (1) Prescription composition:

[0058] Torsemide 5g

[0059] Microcrystalline Cellulose 65g

[0060] Carboxymethyl Starch Sodium 6g

[0061] Hypromellose 15g

[0062] Stevia 6g

[0063] Talc powder 3g

[0064] 70% ethanol appropriate amount

[0065] Makes 1000 pieces

[0066] (2) Preparation process

[0067] 1. Grind the torasemide and auxiliary materials through a 100-mesh sieve, and set aside;

[0068] 2. Accurately weigh the raw and auxiliary materials according to the prescription quantity, first mix microcrystalline cellulose, hydroxypropyl cellulose, and stevioside auxiliary materials evenly, and then mix with the main drug, add 70% ethanol to make a soft material, and granulate with a 20-mesh sieve , dried at 55°C, sieved with a 60-mesh sieve, added sodium starch glycolate and talcum powder and mixed evenly;

[0069] 3. Measure the particle content and calculate the tablet weight;

[0070] 4. Tablet, ready to use.

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Abstract

The present invention relates to one kind of disperse torasemide tablet including torasemide, disintegrating agent and diluent. The disperse torasemide tablet features the disintegrating agent comprising sodium carboxymethyl starch and hydroxypropyl cellulose, and diluent of microcrystalline cellulose. The disperse torasemide tablet has fast disintegration, high dispersing homogeneity, high leaching degree and high stability, and is used in treating heart failure, dropsy and cerebral edema caused by nephrosis and hepatopathy, hypertension, etc.

Description

Technical field: [0001] The invention relates to a torasemide dispersible tablet, a preparation method and a medical application thereof, and belongs to the technical field of medicine. Background technique: [0002] Torasemide is a pyridine sulfonylurea loop diuretic, its chemical name is: N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl )amino]-3-pyridinesulfonamide. The structural formula is as follows: [0003] [0004] Molecular formula: C 16 h 20 N 4 o 3 S [0005] Molecular weight: 348.43 [0006] Loop diuretics are widely used to treat various types of edema, and the common adverse reaction is hypokalemia. Torasemide not only has a strong diuretic effect but also has less potassium loss, which is related to its competitive inhibition of aldosterone. [0007] Torsemide can be used for the treatment of edema caused by congestive heart failure, kidney disease or liver disease and the maintenance treatment of cerebral edema, and it can also be used for t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61K9/20A61P7/10
Inventor 周卓和
Owner 周卓和
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