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Ginkgo leaf extract composition and its prepn
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An extract and technology of ginkgo biloba, applied in the field of composition containing ginkgo biloba extract and its preparation, can solve the problems of low bioavailability, difficult absorption, and high polarity of ingredients
Active Publication Date: 2006-05-17
SHINEWAY PHARMA GRP LTD
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[0086] Weigh the prescribed amount of ginkgo leaf extract and Gelucire44 / 14, heat at 40°C to melt Gelucire44 / 14, grind and mix evenly, add the prescribed amount of lactose and sodiumcarboxymethyl cellulose, mix evenly, and add an appropriate amount of 5% PVP After wetting the ethanol solution, pass through a 22-mesh sieve to granulate, after drying at 35°C, pass through a 22-mesh sieve for granulation, mix with magnesiumstearate evenly, and press into tablets to obtain Ginkgo biloba leaves.
[0096] Weigh the prescription amount of ginkgo biloba extract and polyoxyethylene sorbitan monooleate, stir to mix evenly, add micropowder silica gel, starch, sugarpowder, essence, grind to mix evenly, moisten with appropriate amount of 65% ethanol and pass Granulate with a 22-mesh sieve, dry at 35°C, and granulate with a 22-mesh sieve to obtain Ginkgo biloba extract granules.
[0104] Heat and melt the prescribed amount of Gelucire 50 / 13 at 50°C, add the prescribed amount of Ginkgo biloba extract, dextrin, and powdered sugar, grind and mix evenly, and fill capsules to obtain Ginkgo biloba extract capsules.
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Abstract
The present invention relates to medicine preparation technology, and is especially ginkgo leaf extract composition and its preparation process. The present invention features that the composition contains ginkgo leaf extract and / or ginkgo leaf extract-phosphotide compound, and surfactant. The composition of the present invention has obviously raised bioavailability of ginkgo leaf extract and high curative effect.
Description
technical field [0001] The invention relates to the field of pharmaceutical preparations of natural medicines, in particular to a composition containing ginkgo biloba extract and a preparation method thereof. Background technique [0002] Ginkgo biloba (Ginkgo biloba) is a plant of the genusGinkgo in the Ginkgo family. It is also known as ginkgo tree and Gongsun tree. It is one of the oldest plants. No. 1 in the world. Ginkgo biloba L.extract (GbE) is a light yellow powdery substance extracted and purified from the dried leaves of Ginkgo biloba. However, flavonoids, terpenoid lactones, and polyprenyl alcohols are considered to be the main active ingredients, and ginkgolic acid (abbreviated as ginkgolic acid) is the main toxic ingredient. Among them, flavonoids mainly exist in the form of flavonoid glycosides, which have the effect of scavenging free radicals; terpenoids are potent platelet activating factor (PAF) antagonists, and both are important active ingredients in G...
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