Compound licorice root medicinal preparation and preparing method thereof

A pharmaceutical preparation, the technology of compound licorice, applied in the field of medicine, can solve problems such as vomiting, nausea, unwillingness to accept, inconvenient use, etc., and achieve the effect of relieving gastrointestinal smooth muscle spasm, reducing the trouble of taking it, and having a broad market prospect

Inactive Publication Date: 2006-06-21
NANJING VARSAL MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to prevent glycyrrhizin, the active ingredient in licorice liquid extract, from precipitation of glycyrrhizic acid in an acidic environment, compound licorice oral solution is added with concentrated ammonia water to adjust the pH value. Concentrated ammonia water has a strong odor and can also stimulate the throat mucous membrane , easily cause vomiting, nausea and other adverse reactions, and the oral liquid is easy to precipitate, moldy and deteriorate, and inconvenient to use; while the patent application number disclosed in the Chinese Patent Gazette is "96100065", a...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] Embodiment 1 of the present invention: licorice liquid extract 120ml, compound camphor tincture 180ml, guaiacol glyceryl ether 5g

[0157] Put 0.6% kappa-type carrageenan, 0.2% amidated low-ester pectin, and 8% sucrose in cold water according to the mass percentage, stir to disperse them, soak for 20-30min, make the matrix fully absorb water and swell, and then stir , heating, and filtering; add licorice liquid extract, compound camphor tincture, and guaiacol glyceryl ether into the matrix solution, mix evenly, add sodium bicarbonate, adjust the pH to 8.0-9.0, quickly add it to the sterilized container, seal it, Sterilize, quickly cool down to about 30°C, condense, and dry to obtain a gel. This product is taken orally, three times a day, 2 bags each time, 15g per bag.

Embodiment 2

[0158] Embodiment 2 of the present invention: licorice liquid extract 120ml, compound camphor tincture 180ml, guaiacol glyceryl ether 5g

[0159] Take the above prescription amount of licorice liquid extract, compound camphor tincture, and guaiacol glyceryl ether, mix well, add sodium bicarbonate to adjust the pH value to 8.0-9.0, use polyethylene glycol 4000 as the base, and follow the drug: base = 1: Add polyethylene glycol 4000 at a weight ratio of 2, mix well, use a dropper with an inner diameter of 4.0mm and an outer diameter of 6.0mm, drop the temperature at 70°C, drop speed at 25-35d / min, and drop distance at 4cm. Put it into a 120cm long cooling column, then use methyl silicone oil as the cooling liquid, cool, and pelletize to obtain the drop pill preparation.

Embodiment 3

[0160] Embodiment 3 of the present invention: licorice liquid extract 120ml, compound camphor tincture 180ml, guaiacol glyceryl ether 5g

[0161] Take the above prescription amount of licorice liquid extract and guaiacol glyceryl ether, add compressible starch with a ratio of 1:3 to the drug, and cross-linked polyvinylpyrrolidone with a ratio of 1:3 to the drug. The vinylpyrrolidone aqueous solution is made into a soft material, granulated through a No. 2 sieve, and air-dried at 50-60 ° C. The dry granules are then granulated through a No. 3 sieve. Add sodium carboxymethyl starch at a ratio of 1:1.5 to the drug, and mix , sprayed into compound camphor tincture, pressed into tablets, and then coated, Opadry 2 was used as the coating material, and the top spray method was used for coating: the nozzle diameter was 1mm, the fluidizing air volume was 100m3 / h, the air inlet temperature was 50°C, and the bed temperature 30°C, atomization pressure 0.15MPa, spray rate 8mL / min, to obtai...

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PUM

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Abstract

The present invention is one kind of compound licorice preparation and its preparation process. The compound licorice preparation is orally taken gel, coated tablet, capsule or dripping pill prepared with licorice extractum, compounding camphor tincture, guaiacol, glycerin ether and supplementary material. Compared with available technology, the present invention has the advantages of high curative effect, easy taking and high bioavailability. It is used in trachitis, pharyngolaryngitis, etc. The present invention also provides the preparation process.

Description

technical field [0001] The invention relates to a compound licorice medicinal preparation and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Compound licorice mixture, also known as Brown mixtrure, is mainly composed of licorice liquid extract, camphor, opium tincture, benzoic acid, star anise oil, antimony potassium tartrate, etc. Stimulate the mucous membrane, and have the effect of relieving spasm of gastrointestinal smooth muscle. It is mainly used for bronchitis, pharyngitis and bronchial asthma. Many pharmaceutical workers have done a lot of research on it, but in view of the toxicity of potassium antimony tartrate, the medicinal specifications of potassium antimony tartrate were canceled in the early 1990s, and the Chinese Pharmacopoeia (1995 edition) has deleted this variety. For this reason, in 1999, the National Drug Safety Supervision Department organized a re-evaluation of compound licorice mixture. Ac...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/00A61K9/16A61K9/20A61K9/48A61P11/00A61P11/04
Inventor 周霞
Owner NANJING VARSAL MEDICINE TECH DEV
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