Compound licorice root medicinal preparation and preparing method thereof

Abstract

The present invention is one kind of compound licorice preparation and its preparation process. The compound licorice preparation is orally taken gel, coated tablet, capsule or dripping pill prepared with licorice extractum, compounding camphor tincture, guaiacol, glycerin ether and supplementary material. Compared with available technology, the present invention has the advantages of high curative effect, easy taking and high bioavailability. It is used in trachitis, pharyngolaryngitis, etc. The present invention also provides the preparation process.

Description

technical field [0001] The invention relates to a compound licorice medicinal preparation and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Compound licorice mixture, also known as Brown mixtrure, is mainly composed of licorice liquid extract, camphor, opium tincture, benzoic acid, star anise oil, antimony potassium tartrate, etc. Stimulate the mucous membrane, and have the effect of relieving spasm of gastrointestinal smooth muscle. It is mainly used for bronchitis, pharyngitis and bronchial asthma. Many pharmaceutical workers have done a lot of research on it, but in view of the toxicity of potassium antimony tartrate, the medicinal specifications of potassium antimony tartrate were canceled in the early 1990s, and the Chinese Pharmacopoeia (1995 edition) has deleted this variety. For this reason, in 1999, the National Drug Safety Supervision Department organized a re-evaluation of compound licorice mixture. Ac...

AI Technical Summary

Problems solved by technology

However, in order to prevent glycyrrhizin, the active ingredient in licorice liquid extract, from precipitation of glycyrrhizic acid in an acidic environment, compound licorice oral solution is added with concentrated ammonia water to adjust the pH value. Concentrated ammonia water has a strong odor and can also stimulate the throat mucous membrane , easily cause vomiting, nausea and other adverse reactions, and the oral liquid is easy to precipitate, moldy and deteriorate, and inconvenient to use; while the patent application number disclosed in the Chinese Patent Gazette is "96100065", and the name is "Children Xiaoer Xiaoyanzhikeling and its preparation process" application, the use of sulfadiazine has relatively large side effects, and can cause urinary system damage, allergic reactions, occasional leukopenia and agranulocytosis in hematopoietic system reactions, liver function damage, and gastrointestinal reactions such as nausea and vomiting; now Some of these varieties and dosage forms are not suitable for children, the elderly and other patients with poor swallowing function. Patients have certain difficulties in using existing products and are not willing to accept them.