SD-Zn irradiated biological skin and its prepn process

A kind of irradiation and biological technology, applied in the direction of medical science, prosthesis, etc., can solve the problems of unfavorable prevention and treatment of infected wounds, affecting the treatment effect, liquefaction, etc.

Active Publication Date: 2006-08-02
天津市托福医用原子能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The method of using pigskin, allogeneic skin, etc. as biological dressings to treat burn wounds has a long history, but there are disadvantages in the treatment, such as rejection, poor adhesion, and liquefaction of biological skins. Affect the patient's pain, and leave scars or pigmentation in the donor area
[0003] The reason why above-mentioned defects are caused is that the preparation method of the previous bio-skins is improper: some are immersed in heavy metal silver, and as we all know, heavy metals are harmful to the human body, and after silver is irradiated, the antibacterial effect decreases, which is unfavorable for the prevention and treatment of infected wounds; Some of the radiation time is too long, and the irradiation dose is as high as 6 million rads, causing the cell activity of the bio-skin to be completely killed, so that the bio-skin without cell activity can only be used as high-grade gauze; some bio-skins are too thick, reaching 0.4 ~0.8mm, without perforation, poor air permeability, weak adhesion, and will fall off in three days. At this time, the autologous skin has not yet grown out, which will affect the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] 60kg captive healthy pigs, the skin is taken within 6 hours after killing, the hair is shaved with a knife, and cut into 300×600cm 2 , use a blade to degrease and cut it clean, and grasp the skin thickness at 2-3mm; soak the cut skin in detergent for 5 minutes; until the degreased skin has no greasy feeling; put the skin on the drum skin cutter , adjust the tool, master the cutting thickness at 0.2-0.3mm, wash the peeled skin with a 1:10 mixture of detergent and tap water until it is clean; remove the washed skin, keep 10-20% water, and put Submerge the skin in physiological saline until the skin is soaked in the liquid until milky white, remove and keep 10-20% water content; punch holes; apply an absorbent material such as a towel to smooth the above-mentioned skin with the dermis facing upwards Drug immersion treatment—the liquid medicine is: distilled aqueous solution containing 10% sulfadiazine zinc, and the immersion time is 10 minutes: after the skin slice is abso...

example 2

[0028] 40kg captive healthy pigs, take the skin within 4 hours after killing, shave with a knife, cut into 300×600cm 2 , use a blade to degrease and cut it clean, and grasp the skin thickness at 2-3mm; soak the cut skin in detergent for 5 minutes; until the degreased skin has no greasy feeling; put the skin on the drum skin cutter , adjust the tool, master the cutting thickness at 0.2-0.3mm, wash the peeled skin with a 1:10 mixture of detergent and tap water until it is clean; remove the washed skin, keep 10-20% water, and put Submerge the skin in physiological saline until the skin is soaked in the liquid until milky white, remove and keep 10-20% water content; punch holes; apply an absorbent material such as a towel to smooth the above-mentioned skin with the dermis facing upwards Drug immersion treatment - the liquid medicine is: distilled aqueous solution containing 1% sulfadiazine zinc, and the immersion time is 3 minutes: after the skin slice is absorbed by the immersion...

example 3

[0031] 70kg healthy pigs in captivity, take the skin within 5 hours after killing, shave with a knife, cut into 300×600cm 2 , use a blade to degrease and cut cleanly, and the thickness of the skin is 2-3mm; soak the cut skin in detergent for 5 minutes until the degreased skin has no greasy feeling; put the skin on the drum skin cutter , adjust the tool, master the cutting thickness at 0.4-0.5mm, wash the skin with a 1:10 mixture of biological detergent and tap water until it is clean; remove the washed skin, keep 10-20% water, and put it in normal saline Immerse the skin until the skin is soaked in the liquid to milky white, remove it, and keep the water content of 10-20%; spread it flat with an absorbent material such as a towel, and evenly soak the skin with the dermis facing upwards——Potion It is: distilled aqueous solution containing 8% sulfadiazine zinc, and the soaking time is 8 minutes; after the soaking liquid of the skin piece is absorbed, it is folded and packaged ac...

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PUM

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Abstract

The present invention belongs to the field of medical dressing technology, is especially the technology of biological skin as foreign substituting skin, and aims at provides biological skin processing method to improve the performance of biological skin, including abacterial performance, no repulsion reaction and even high cell activity and biological affinity. The SD-Zn irradiated biological skin is made with piglet skin, has thickness of 0.2-0.5 mm and contains sulfadiazine zinc. Its preparation process includes the steps of : taking piglet, scraping to eliminate hair, cutting, defatting, cutting to 0.2-0.5 mm thickness, washing, soaking in medicine solution of sulfadiazine zinc, packing, irradiating and cold storing.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to the field of replacing allogeneic skin with biological skin. Background technique [0002] The method of using pigskin, allogeneic skin, etc. as biological dressings to treat burn wounds has a long history, but there are disadvantages in the treatment, such as rejection, poor adhesion, and liquefaction of biological skins. It not only reduces the pain of the patient, but also leaves scars or pigmentation in the donor area. [0003] The reason why above-mentioned defects are caused is that the preparation method of the previous bio-skins is improper: some are immersed in heavy metal silver, and as we all know, heavy metals are harmful to the human body, and after silver is irradiated, the antibacterial effect decreases, which is unfavorable for the prevention and treatment of infected wounds; Some of the radiation time is too long, and the irradiation do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/38
Inventor 许绍海刘群于维陆
Owner 天津市托福医用原子能科技有限公司
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