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Dispersion tablet for treating acute and chronic gastroenteritis and its preparation technoloyg

A technology for gastroenteritis and dispersible tablets, applied in the field of dispersible tablets for the treatment of acute and chronic gastroenteritis, can solve the problems of many impurities, large dosage, slow disintegration and onset of effect, etc.

Inactive Publication Date: 2006-08-30
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because Changyanning syrup is inconvenient to use and carry, the quality is not as stable as solid preparations, it is not easy to store during use, the dosage is not accurate, and diabetic patients are taboo to use it; while the traditional Changyanning tablets only use simple extraction and removal measures, there are many impurities, and it is difficult to take it. Large dose, slow disintegration and onset of action, bioavailability needs to be improved
[0003] At present, domestic drugs for the treatment of gastrointestinal diseases are mainly concentrated in gastric ulcer, digestive aids and gastric motility drugs, among which there are relatively few drugs for the treatment of enteritis

Method used

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  • Dispersion tablet for treating acute and chronic gastroenteritis and its preparation technoloyg
  • Dispersion tablet for treating acute and chronic gastroenteritis and its preparation technoloyg

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dijin grass 1650g, yellow hair grass 2250g, camphor tree 1650g, fennel 825g, maple leaves 825g, microcrystalline cellulose 107.5g crospovidone 105.2g, magnesium stearate 2.3g.

[0016] Preparation method: Take the prescription amount of Dijincao, saffron, camphor tree, fenugreek, and maple leaves, add water to decoct twice, each time for 2 hours, add 15 times the amount of water for the first time, and add 12 times for the second time amount of water. Combine the decoctions, filter, concentrate the filtrate to a clear paste with a relative density of 1.20 at 80°C, add 2 times the amount of 95% ethanol, stir, refrigerate for 12 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure, and store at low temperature Dry to obtain dry extract, pulverize, pass through a 100-mesh sieve to obtain dry extract powder, and set aside. Microcrystalline cellulose and crospovidone were respectively passed through 100 mesh, mixed with dry extract powder, 80...

Embodiment 2

[0018] Dijin grass 1450g, yellow hair ear grass 1970g, camphor tree 1450g, fennel 725g, maple leaves 725g, lactose 12.27g

[0019] Low-substituted hydroxypropyl cellulose 9g, povidone k30 1.25g, talcum powder 0.23g.

[0020] Preparation method: Take the prescribed amount of Dijincao, saffron, camphor tree, fennel, and maple leaves, add water to decoct twice, each time for 2 hours, add 15 times the amount of water for the first time, and add 12 times for the second time amount of water. Combine the decoctions, filter, concentrate the filtrate to a clear paste with a relative density of 1.20 at 80°C, add 2 times the amount of 95% ethanol, stir, refrigerate for 12 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure, and store at low temperature Dry to obtain dry extract, pulverize, pass through a 100-mesh sieve to obtain dry extract powder, and set aside. Separately take lactose, low-substituted hydroxypropyl cellulose, and povidone K30 to pass ...

Embodiment 3

[0022] Dijin grass 1850g, yellow hair ear grass 2530g, camphor tree 1850g, fennel 925g, maple leaves 925g, lactose 12.27g

[0023] Low-substituted hydroxypropyl cellulose 9g, povidone k30 1.25g, talcum powder 0.23g.

[0024] Preparation method: Take the prescribed amount of Dijincao, saffron, camphor tree, fennel, and maple leaves, add water to decoct twice, each time for 2 hours, add 15 times the amount of water for the first time, and add 12 times for the second time amount of water. Combine the decoctions, filter, concentrate the filtrate to a clear paste with a relative density of 1.20 at 80°C, add 2 times the amount of 95% ethanol, stir, refrigerate for 12 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure, and store at low temperature Dry to obtain dry extract, pulverize, pass through a 100-mesh sieve to obtain dry extract powder, and set aside. Separately take lactose, low-substituted hydroxypropyl cellulose, and povidone K30 to pass ...

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Abstract

A Chinese medicine in the for of dispersing tablet for treating acute or chronic gastroenteritis is prepared from cliff starwort herb, goldhair hedyotis herb, camphor tree, elsholtzia herb, maple leaf, microcrystalline cellulose, cross-linking povidone and magnesium stearate through extracting in water, depositing in alcohol, adding filler, disintegrant and alcohol, stirring, granulating, drying, die pressing and coating.

Description

technical field [0001] The invention relates to a dispersible tablet for treating acute and chronic gastroenteritis and its preparation process Background technique [0002] Changyanning Tablets and Changyanning Syrup, which are made of Jiangxi authentic medicinal materials, chrysanthemum chrysanthemum, dijincao, fennel, camphor, and maple leaves, are Chinese patent medicines exclusively developed and produced by Jiangxi Tianshikang Traditional Chinese Medicine Co., Ltd. It is effective in treating acute and chronic gastroenteritis, diarrhea, bacillary dysentery and dyspepsia in children. After more than 30 years of clinical application, we found that it is necessary to develop Changyanning Chinese patent medicine in depth. Because Changyanning syrup is inconvenient to use and carry, the quality is not as stable as solid preparations, it is not easy to store during use, the dosage is not accurate, and diabetic patients are taboo to use it; while tr...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/20A61P1/04A61P1/12
Inventor 吴朝阳徐发红陈科茂黄经球
Owner JIANGXI HERBI SKY CO LTD
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