Chitose base self-assembly nano microcapsule preparation method and its drug release regulation method

A technology of nano-microcapsules and chitosan, applied in the N field, can solve the problem that microcapsules cannot reach nanometer size, and achieve the effects of improving drug release rate, simple operation and ensuring safety.

Inactive Publication Date: 2006-10-04
HUAQIAO UNIVERSITY
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  • Abstract
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Problems solved by technology

The use of chitosan-based materials as drug-controlled release carriers has been reported, such as pH-responsive hydrogels, polyelectrolyte complex microcapsules, etc., and the microcapsules prepared by these technologies cannot reach nanometer size.

Method used

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  • Chitose base self-assembly nano microcapsule preparation method and its drug release regulation method
  • Chitose base self-assembly nano microcapsule preparation method and its drug release regulation method
  • Chitose base self-assembly nano microcapsule preparation method and its drug release regulation method

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Embodiment Construction

[0029] In order to better understand and implement, the following combination figure 1 , figure 2 , image 3 , Figure 4 The preparation method of the chitosan-based self-assembled nano-microcapsule and the drug release regulation method of the present invention are described in detail with the examples.

[0030] The preparation method of N, N-bis-octyl chitosan self-assembled nano-medicine microcapsules is realized by the following scheme: 0.1G N, N-bis-octyl chitosan is dissolved in 24mL chloroform, Add 8 mL of V at a concentration of 4.0 mg / mL B12 aqueous solution. Bath ultrasonication for 15-30 minutes to form a W / O emulsion. The resulting emulsion was evaporated under reduced pressure to remove chloroform to a semi-solid gum. It was placed in a vacuum desiccator at room temperature for 12 hours to further remove remaining chloroform. Then ultrasonicate in a powerful sonicator for 3-12 minutes to obtain drug-embedded N, N-bis-octylated chitosan-based self-assembled...

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Abstract

The invention discloses a process for preparing chitosan-based self-assembled nano microcapsule and the pharmaceutical release and regulation method, wherein the nano pharmaceutical microcapsule is prepared through using N,N-dialkylated chitosan as the capsule material, employing modified retrograde evaporation method according to the principle of the self-assembly technique, i.e. carrying out a second supersonic operation before centrifugal separation. The obtained microcapsule has a dimension distribution between 100-250nm.

Description

technical field [0001] The invention relates to a new drug dosage form technology in the field of pharmaceutical industry, and specifically relates to a preparation method of N, N-dialkylated chitosan self-assembled nanometer medicinal microcapsules and a method for regulating and controlling drug release. Background technique [0002] Chitosan is a natural polysaccharide that is non-toxic, non-irritating, non-sensitizing, and non-mutating. It has good biocompatibility and biodegradability. Recently, chitosan has been found to promote drug absorption. Chitosan and its derivatives are promising drug release carriers. It has been reported that chitosan-based materials are used as drug-controlled release carriers such as pH-responsive hydrogels, polyelectrolyte complex microcapsules, etc., but the microcapsules prepared by these techniques cannot reach nanometer size. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36
Inventor 李明春辛梅华
Owner HUAQIAO UNIVERSITY
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