Stable freeze-dried formulation containing multiple kinds of vitamin and its preparation method

A technology for freeze-dried preparations and vitamins, which is applied in the field of pharmaceutical preparations and can solve the problems of unsafe human body and poor stability.

Inactive Publication Date: 2006-10-11
CHONGQING PHARMA RES INST +1
View PDF2 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Fat emulsion for injection containing four fat-soluble vitamins has been marketed at home and abroad, but it is a fat emulsion rather than a transparent solution, and its stability is poor
The thirteen vitamins M.V.I.-pediatricd, M.V.I.-Adult, Infuvite-pediatic, and Infuvite-Adult preparations lis...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: Four kinds of fat-soluble vitamins for injection (glycocholic acid and soybean lecithin are used as solubilizers)

[0052] prescription:

[0053] Vitamin A (Vitamin A Palmitate) 3,300,000 IU

[0054] Vitamin D 2 200,000 IU

[0055] Vitamin E 10,000 IU

[0056] Vitamin K 1 0.15g

[0057] Glycocholic Acid 140g

[0058] Soy Lecithin 112.5g

[0059] Glycine 250g

[0060] Sodium hydroxide solution, hydrochloric acid solution to adjust the pH to 5.9

[0061] 1000 bottles

[0062] Preparation method: weigh vitamin A palmitate, vitamin E, and vitamin K in prescribed quantities 1 and vitamin D 2 Dissolved with 50ml of ethanol to obtain solution 1; take the prescribed amount of glycocholic acid, dissolve it with water for injection, and adjust the pH to 5.8-6.0 with 4mol / L sodium hydroxide solution and 0.1mol / L hydrochloric acid solution to obtain solution 2. Add the prescription amount of...

Embodiment 2

[0078] Vitamin A (Vitamin A Palmitate) 3,300,000 IU

[0079] Vitamin D 3 200,000 IU

[0080] Vitamin E 10,000 IU

[0081] Vitamin K 1 0.15g

[0082] Vitamin C 200.00g

[0083] Thiamine Hydrochloride 6.73g

[0084] Equivalent to Thiamin 6.00g

[0085] Riboflavin Sodium Phosphate 4.92g

[0086] Equivalent to Vitamin B 2 (Riboflavin) 3.6g

[0087] Vitamin B 6 6.00g

[0088] Niacinamide 40.00g

[0089] Panthenol 15.00g

[0090] Glycine 250.00g

[0091] Glycocholic acid 140.00g

[0092] Soy Lecithin 112.50g

[0093] Sodium hydroxide solution, hydrochloric acid Adjust to pH5.9

[0094] 1000 bottles

[0095] Preparation method: Weigh soybean lecithin, vitamin A palmitate, vitamin E, and vitamin K for injection in prescription quantities 1 and vitamin D 3 Dissolve in 60ml of ethanol to obtain solution 1; weigh the prescribed amount of glycocholic acid and add an appropriate amount o...

Embodiment 3

[0122] Vitamin A 3.3 million IU

[0123] Vitamin D 3 200,000 IU

[0124] Vitamin E 10,000 IU

[0125] Vitamin K 1 0.15g

[0126] Vitamin C 200.00g

[0127] Thiamine Hydrochloride 6.73g

[0128] Equivalent to Thiamin 6.00g

[0129] Riboflavin Sodium Phosphate 4.92g

[0130] Equivalent to Vitamin B 2 (Riboflavin) 3.6g

[0131] Vitamin B 6 6.00g

[0132] Niacinamide 40.00g

[0133] Panthenol 15.00g

[0134] Folic acid 0.60g

[0135] Biotin 0.060g

[0136] Vitamin B 1 5.0mg

[0137] Glycine 250.00g

[0138] Glycocholic acid 140.00g

[0139] Soy Lecithin 112.50g

[0140] NaOH Adjust to pH 5.9

[0141] 1000 bottles

[0142] Weigh the prescribed amount of soybean lecithin for injection and dissolve it in 100ml ethanol to obtain solution 1; weigh the prescribed amount of glycocholic acid and add appropriate amount of water for injection to dissolve, and adjust the pH to 5...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a stable compound containing a plurality of vitamins and the method for preparing same. The compound comprises at least four kinds of fat-soluble vitamin, cholate, phosphatide and carriers or findings acceptable by pharmacy. The compound also comprises water soluble vitamins. The compound is a clear and transparent solution. The preparing method comprises: (1) dissolving the fat-soluble vitamin with liquid containing ethanol; (2) removing ethanol. The compound is used as nutriment for patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a stable freeze-dried preparation containing multiple vitamins and a preparation method thereof, wherein the freeze-dried preparation contains at least four fat-soluble vitamins, bile acids, phospholipids and pharmaceutically acceptable carrier or excipient. The lyophilized preparation was dissolved in water as a clear and transparent solution. A preparation method of the freeze-dried preparation comprises at least two steps in the preparation process: (1) dissolving fat-soluble vitamins in liquid containing ethanol; (2) removing ethanol. Background technique [0002] Cholic acid and phospholipids have been reported as solubilizers for insoluble substances: a kind of intravenous infusion containing cholate, phospholipids and ethanol is described in GB1502929; twelve kinds of vitamin Cernevit for injection of Baxter Company use cholic acid Salt and lecithin are used as...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/00A61K9/19A61K31/07A61K31/122A61K31/355A61K31/59
Inventor 王显著李波冉伟陈振华赵小萍
Owner CHONGQING PHARMA RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap