Injection of long-chain fat from zedoary oil and its prepn process

A technology of turmeric oil and injection, applied in the field of medicine, can solve the common problems of allergic reactions, anaphylactic shock, etc.

Inactive Publication Date: 2006-10-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the most commonly used zedoary oil preparations are zedoary oil glucose injection and zedoary oil injection, which are mainly used as antiviral drugs, and the administration form is intravenous infusion. Both preparations use Tween

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 100 grams of caprylic glyceride for injection and 100 grams of soybean oil for injection and mix, heat in a water bath to 75 ℃, add 12 grams of soybean phospholipids for injection, stir to dissolve, add 0.1 grams of turmeric oil, stir until dissolved, add growth 0.05 g of phenol, stir and mix well to obtain the oil phase. Measure 860 ml of water for injection, add 22.5 g of glycerin, stir to dissolve, and heat to 75°C to obtain the water phase. Mix the oil phase and the water phase at a temperature of 75°C, emulsify with a shear emulsifier for 5 minutes (rotating speed 1600 rpm) to obtain colostrum, and homogenize the colostrum with a micro-jet high-pressure homogenizer (pressure 5000 psi) three times , Adjust the pH to 8.5 with sodium hydroxide solution or hydrochloric acid solution, quantify the water for injection to 1000ml, subpackage, fill with nitrogen, and sterilize at 115°C for 30 minutes to obtain turmeric oil medium and long-chain fat emulsion injection. The...

Embodiment 2

[0028] Weigh 100 grams of caprylic glyceride for injection and 200 grams of safflower seed oil for injection and mix, heat in a water bath to 65°C, add 12 grams of egg yolk phospholipids for injection, stir to dissolve, add 5 grams of turmeric oil, stir until dissolved, Add 0.1 g of tocopherol, stir and mix to obtain the oil phase. Measure 700 ml of water for injection, add 17.6 g of glycerin, stir to dissolve, and heat to 65°C to obtain the water phase. Mix the oil phase and the water phase at 65°C, emulsify with a shear emulsifier for 5 minutes (rotating speed 3000 rpm) to obtain colostrum, homogenize the colostrum with a high-pressure micro-jet homogenizer (pressure 3000 psi) three times , Adjust the pH to 8.5 with sodium hydroxide solution or hydrochloric acid solution, quantify the water for injection to 1000ml, subpackage, fill with nitrogen, and sterilize at 115°C for 30 minutes to obtain turmeric oil medium and long-chain fat emulsion injection. The average particle size o...

Embodiment 3

[0030] Weigh 50 grams of caprylic acid glyceride and 100 grams of corn oil and mix, heat to 75 ℃ in a water bath, add 12 grams of soybean phospholipids for injection, stir to dissolve, add 10 grams of turmeric oil, stir until dissolved, add 1 gram of tocopherol, Stir and mix well to obtain the oil phase. Measure 870 ml of water for injection, add 22.5 g of glycerin, stir to dissolve, and heat to 75°C to obtain the water phase. Mix the oil phase and the water phase at a temperature of 75°C, emulsify with a shear emulsifier for 5 minutes (rotating speed 4500 rpm) to obtain colostrum, homogenize the colostrum with a microjet high pressure homogenizer (pressure 10000psi) three times , Adjust the pH to 8.5 with sodium hydroxide solution or hydrochloric acid solution, quantify the water for injection to 1000ml, subpackage, fill with nitrogen, and sterilize at 115°C for 30 minutes to obtain 1000ml of turmeric oil medium and long-chain fat emulsion injection. The average particle size of ...

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Abstract

The emulsified injection is prepared with zedoary oil, middle chain oil for injection, long chain oil for injection, emulsifier, isoosmotic regulator, antioxidant, pH regulator and water for injection. The preparation process include adding emulsifier into the middle chain oil and the long chain oil, heating and stirring to dissolve emulsifier, adding zedoary oil, heating and stirring to dissolve and mix, and adding tocopherol via stirring to obtain oil phase; adding isoosmotic regulator into water for injection, and heating and stirring to dissolve to obtain water phase; mixing the oil phase and the water phase, emulsifying, regulating pH value and adding water for injection to required amount. The preparation has great medicine carrying amount, no toxic side effect, stable property, convenient use and fast and simple preparation, and is suitable for mass production.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a zedoary turmeric oil medium and long-chain fat emulsion injection and a preparation method thereof. Background technique [0002] Curcuma oil is a volatile oil extracted from the rhizomes of Curcuma ginger, Curcuma Phaeocaulis and Curcuma Guangxi. Its main components are a variety of sesquiterpenes, including curcumol, curcumone, curcumone, β-sitosterol, etc. More than 20 kinds of chemical components, the main pharmacological effects of which are anti-pathogen, anti-tumor, anti-inflammatory, anti-thrombosis, enhancement of immunity and stimulation of smooth muscle. In particular, it has significant antiviral and antitumor effects. Zedoary oil has a significant inhibitory effect on influenza virus, influenza virus A, parainfluenza virus, respiratory syncytial virus, and Staphylococcus aureus. In recent years, studies have shown that turmeric oil can interfere with tumor cell DNA syn...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/107A61P7/02A61P29/00A61P31/00A61P35/00
Inventor 陈建明黄尊动
Owner TIANJIN TASLY PHARMA CO LTD
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