Preparing method for oral instant-dissolving tablet for calming brain

A technology of oral instant tablets and Naoan, which is applied in the field of preparation of Naoan oral instant tablets, to achieve the effects of solving the difficulty of taking medicine, shortening the time of absorption, and improving the effective utilization

Inactive Publication Date: 2006-10-25
上海祥鹤药业有限公司
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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to improve the original dosage form of Nao'an hard capsule, and the dosage form of the new preparation is an oral instant tablet, which not only solves the problem of taking medicine for comatose patients and patients with dysphagia, but also improves the content of active ingredients

Method used

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Embodiment Construction

[0018] The present invention is further described below:

[0019] Recipe: 950 grams of Chuanxiong, 600 grams of Angelica, 550 grams of safflower, 120 grams of ginseng, 8 grams of borneol;

[0020] Fine powder configuration: Ligusticum chuanxiong and Angelica plus 95% ethanol to extract twice, combine the filtrates, concentrate under reduced pressure at 55°C to a clear paste with a relative density of 1.1, add decoctions of safflower and water to combine and concentrate to a clear paste with a density of 1.1, and mix the two The extract is mixed with ginseng fine powder, dried in vacuum at 55°C, crushed and mixed into fine powder;

[0021] Finished product preparation: take the amount of dry paste as 1, weigh 15% each of citric acid, sodium bicarbonate, cross-linked carboxymethyl starch sodium, microcrystalline cellulose and lactose, mix borneol and all auxiliary materials with the above-mentioned fine powder Chuanxiong, The safflower alcohol and water-extracted dry cream powd...

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Abstract

The present invention relates to preparation method of Nao'an oral quick-dissolving tablet. It is characterized by that it is an improvement on original Nao'an hard capsule preparation. Said method makes the aqueous extract of Chinese medicinal materials of ligusticum root and Chinese angelica root undergo the processes of vacuum-drying and concentration treatment, so that in the active component extract obtained by the invented method the ligustilide content is greater than or equal to 0.405% and ferulic acid content is greater than or equal to 0.0816%.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a preparation method of Nao'an oral instant tablets. Background technique [0002] Stroke has high morbidity, high mortality, and high disability rate, and is one of the three major diseases that seriously endanger the health and life of middle-aged and elderly people. With the aging of the population in our country, the harm of stroke is becoming more and more serious, and there is a trend of younger incidence. According to reports, the incidence of stroke in my country is 1.30 / 100,000, and the prevalence rate is 250 / 100,000. Based on this estimate, there are about 3.25 million stroke patients in my country, and 1.7 million new cases of stroke occur every year. The disability rate of stroke is extremely high, and about a quarter of the surviving patients lose their ability to take care of themselves, which requires the state and society to invest a...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/20A61K31/045A61P9/10
Inventor 王桂清李学松顾祯茂王春安
Owner 上海祥鹤药业有限公司
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