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Children cetirizine hydrochloride composition

A technology of cetirizine hydrochloride and its composition, which is applied in the field of cetirizine hydrochloride composition freeze-dried orally disintegrating tablets for children and its preparation, to achieve the goals of reducing migratory activity, good anti-allergic effect, and shortening the freeze-drying time Effect

Active Publication Date: 2013-05-22
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablets are pressurized, disintegrate slowly, have low bioavailability, and are difficult for some patients to swallow, especially for children.

Method used

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  • Children cetirizine hydrochloride composition
  • Children cetirizine hydrochloride composition
  • Children cetirizine hydrochloride composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Taking 10mg / tablet as an example to prepare children's cetirizine hydrochloride composition freeze-dried orally disintegrating tablets,

[0048] Prescription: 1000 tablets

[0049]

[0050] Preparation Process:

[0051] Dissolve the cetirizine hydrochloride of the prescription amount in the tert-butanol (solution a) of the prescription amount, stir and dissolve at normal temperature, continue stirring, dissolve the mannitol and sucralose of the prescription amount in the purified water total 70%-80% of purified water (solution b); then dissolve the prescription amount of gelatin in 20%-30% of prescription water in purified water (solution c), and heat until completely dissolved; combine the above b and c The two solutions are formed into solution d, and stirred evenly, and then the mixed solution is cooled to below 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the cetiriz...

Embodiment 2

[0053] Taking 10mg / tablet as an example to prepare children's cetirizine hydrochloride composition freeze-dried orally disintegrating tablets,

[0054] Prescription: 1000 tablets

[0055]

[0056] Preparation Process:

[0057] Dissolve the cetirizine hydrochloride of the prescription amount in the tert-butanol (solution a) of the prescription amount, stir and dissolve at normal temperature, continue stirring, dissolve the mannitol and sucralose of the prescription amount in the purified water total 70%-80% of purified water (solution b); then dissolve the prescription amount of gelatin in 20%-30% of prescription water in purified water (solution c), and heat until completely dissolved; combine the above b and c The two solutions are formed into solution d, and stirred evenly, and then the mixed solution is cooled to below 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the ceti...

Embodiment 3

[0059] Taking 10mg / tablet as an example to prepare children's cetirizine hydrochloride composition freeze-dried orally disintegrating tablets,

[0060] Prescription: 1000 tablets

[0061]

[0062] Preparation Process:

[0063] Dissolve the cetirizine hydrochloride of the prescription amount in the tert-butanol (solution a) of the prescription amount, stir and dissolve at normal temperature, continue stirring, dissolve the mannitol and sucralose of the prescription amount in the purified water total 70%-80% of purified water (solution b); then dissolve the prescription amount of gelatin in 20%-30% of prescription water in purified water (solution c), and heat until completely dissolved; combine the above b and c The two solutions were formed into solution d, and stirred evenly, and then the mixed solution was cooled to below 5°C. Mix the two solutions a and d, stir well, and adjust the pH value to 6.0-6.5 with sodium bicarbonate. According to the specifications of the ce...

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Abstract

The invention discloses a children cetirizine hydrochloride composition, relating to the technical field of medicinal preparations. The children cetirizine hydrochloride composition is composed of a main medicine and adjuvants in a formula and is characterized in that the main medicine is cetirizine hydrochloride and the adjuvants comprise a skeleton agent, a forming agent and a flavoring agent, wherein mannitol is selected as the skeleton agent, gelatin is selected as the forming agent, and sucralose is selected as the flavoring agent; and the proportions of the main medicine and the adjuvants in terms of the total weight of the formula are as follows: 25wt% of cetirizine hydrochloride, 75-79wt% of mannitol, 2-4wt% of gelatin, and 0.1-0.15wt% of sucralose. The invention further provides a freeze-dried orally disintegrating tablet of the children cetirizine hydrochloride composition and a preparation method of the freeze-dried orally disintegrating tablet, wherein the freeze-dried orally disintegrating tablet comprises simple components, is taken without water and chewing, disintegrates in the oral cavity of a human body within 2 seconds, has the advantages of high effect-taking speed, fewer intestinal tract residue, absorption sufficiency, low side effect and good mouthfeel, and is particularly suitable for being taken by infants and babies.

Description

Technical field [0001] The present invention involves the field of drug preparation technology, which specifically involves a pediatric acid hydrochloride composition and a pediatric acid hydrochloride combinations containing the above composition frozen dry oral collapse and its preparation methods. Background technique [0002] Sythidine hydrochloride is a powerful H1 receptor antagonist, which is taken into the body orally and quickly binds to the histamine H1 receptor on the target cell membrane to block histamine to activate target cells.Sidinezine has no obvious anti-choline and anti-5-hydroxylidine.Under normal doses, it is not easy to pass through the blood brain barrier.This product can inhibit the initial histamine transmission of perverted reactions, reducing the swimming activity of inflammatory cells and the release of the later period of the perverted response, so it is also effective to the abnormal response to the delay period.This product is a high -selective H1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P37/08A61K47/42A61P27/02A61K9/20A61K31/495
Inventor 汪六一汪金灿李祖红
Owner HAINAN WEI KANG PHARMA QIANSHAN
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