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Preparation method of Naodesheng orally disintegrating tablets

A technology for oral instant-dissolving tablets and formula is applied in the field of preparation of Naodesheng oral-dissolving tablets, and achieves the effects of improving the effective utilization, solving the difficulty of taking medicine, and shortening the absorption time.

Inactive Publication Date: 2009-04-01
上海市脑血管病防治研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to improve the original Naodesheng tablet, and the new dosage form is an oral instant tablet, which solves the problem of taking medicine for comatose patients and patients with dysphagia

Method used

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  • Preparation method of Naodesheng orally disintegrating tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Formula: Panax notoginseng 78g, Ligusticum chuanxiong 78g, safflower 91g, kudzu root 261g,

[0020] Hawthorn (pitted) 157g;

[0021] Fine powder configuration: take 78g of Panax notoginseng and 130.5g of kudzu root and grind them into fine powder respectively, add the remaining safflower, Chuanxiong, hawthorn and remaining kudzu root to decoct twice, the first time is 1.5 hours, the second time is 1 hour, and the decoction is combined , filtered, and the filtrate was concentrated into a clear paste with a relative density of 1.22 (80° C.), adding kudzu root fine powder and Panax notoginseng fine powder, mixing, drying, and setting aside.

[0022] Finished product preparation: take the amount of dry paste as 1, weigh 10% citric acid, 20% sodium bicarbonate, 15% croscarmellose sodium starch, 20% microcrystalline cellulose, and 25% lactose, and mix all auxiliary materials with The dry cream powder is mixed evenly, pressed into tablets, and it is ready.

Embodiment 2

[0024] Formula: Panax notoginseng 78g, Ligusticum chuanxiong 78g, safflower 91g, kudzu root 261g,

[0025] Hawthorn (pitted) 157g;

[0026] Fine powder configuration: take 78g of Panax notoginseng and 130.5g of kudzu root and grind them into fine powder respectively, add the remaining safflower, Chuanxiong, hawthorn and remaining kudzu root to decoct twice, the first time is 1.5 hours, the second time is 1 hour, and the decoction is combined , filtered, and the filtrate was concentrated into a clear paste with a relative density of 1.25 (80° C.), adding kudzu root fine powder and Panax notoginseng fine powder, mixing, drying, and setting aside.

[0027] Finished product preparation: take the amount of dry paste as 1, weigh 15% of citric acid, 15% of sodium bicarbonate, 20% of croscarmellose sodium starch, 15% of microcrystalline cellulose, and 15% of lactose, and mix all auxiliary materials with The dry cream powder is mixed evenly, pressed into tablets, and it is ready.

Embodiment 3

[0029] Formula: Panax notoginseng 78g, Ligusticum chuanxiong 78g, safflower 91g, kudzu root 261g,

[0030] Hawthorn (pitted) 157g;

[0031] Fine powder configuration: take 78g of Panax notoginseng and 130.5g of kudzu root and grind them into fine powder respectively, add the remaining safflower, Chuanxiong, hawthorn and remaining kudzu root to decoct twice, the first time is 1.5 hours, the second time is 1 hour, and the decoction is combined , filtered, and the filtrate was concentrated into a clear paste with a relative density of 1.24 (80°C), adding kudzu root fine powder and Panax notoginseng fine powder, mixing, drying, and setting aside.

[0032] Finished product preparation: take the amount of dry paste as 1, weigh 13% of citric acid, 18% of sodium bicarbonate, 22% of cross-linked carboxymethyl starch sodium, 18% of microcrystalline cellulose, and 12% of lactose, and mix all auxiliary materials with The dry cream powder is mixed evenly, pressed into tablets, and it is r...

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Abstract

The invention relates to a prepration method of a Naodesheng instant oral tablet. The technical problem to be solved is to improve the formulation of the original Naodesheng tablet, the new preparation type is the instant oral tablet which can not only solve the difficult drug administration problem of patients with coma and difficulty in swallowing, but can also shorten the time of the drug for entering the blood, thereby improving the availability of the drug and being more applicable to treating the patients with stroke.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Naodesheng oral instant tablets. Background technique [0002] As the population ages, the risk of stroke is increasing. Stroke has the characteristics of high morbidity, high mortality and high disability, and is one of the diseases that seriously endanger the health and life of middle-aged and elderly people. Statistics show that the incidence of stroke in China is about 1.30 / 100,000, and the prevalence rate is 250 / 100,000. Based on this calculation, there are 1.7 million new cases of stroke in my country every year. About a quarter of stroke survivors lose their ability to take care of themselves. While suffering from great pain and suffering, stroke patients also bring heavy burdens to society and families. At present, my country's medical resources are not sufficient. According to statistics, stroke accounts for tens ...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/20A61P9/10
Inventor 王桂清俞学海
Owner 上海市脑血管病防治研究所
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