Use of Galangal fruit and its extract in pharmacy

A cardamom and extract technology, which is applied in the field of traditional Chinese medicine, can solve the problems of inhibiting, preventing or treating benign prostatic hyperplasia and the like, and achieves the effects of significant curative effect, low price and inhibiting 5α-reductase activity.

Active Publication Date: 2006-11-01
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there has been no report that cardamom inhibits 5α-reductas

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 red cardamom crude drug

[0026] Take the original drug of red cardamom, that is, the dried and mature seed kernel of Alpinia galanga Willd. After purification, crush and sieve according to the conventional method, make red cardamom fine powder with a particle size of 60-80 mesh, sterilize, and pack Serve.

Embodiment 2

[0027] Example 2 Preparation of Red Cardamom Extract

[0028] Weigh 1000g of cardamom, extract three times with 90% ethanol, the amount of solvent is 8 times, 6 times, 6 times respectively, and the extraction time is 2 hours, 1 hour, 1 hour respectively. Combine the extracts and recover until there is no alcohol smell. Dry under reduced pressure at 50°C to obtain sample A. Weigh 50g of sample A and dissolve it with 150ml of distilled water. The aqueous solution was extracted with petroleum ether, diethyl ether, ethyl acetate, and n-butanol respectively with 3 times the volume, and the solvent was recovered under reduced pressure to obtain samples B (petroleum ether phase), C (ether phase), D (ethyl acetate phase), and E ( Butanol phase), F (water phase). The above-mentioned extraction solvents can be selected and used in combination with different organic solvents as required.

Embodiment 3

[0030] Weigh 1000 g of cardamom, extract three times with 30% ethanol, the amount of solvent is 8 times, 6 times, 6 times respectively, and the extraction time is 2 hours, 1 hour, 1 hour respectively. Combine the extracts and recover until there is no alcohol smell. The red cardamom extract was invented by drying under reduced pressure at 50°C.

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Abstract

An application of galanga galangal fruit and its extract in preparing 5 alpha-reductase inhibitor and the medicines for treating prostatoplasia with high curative effect is disclosed.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine red cardamom, specifically, the application in the preparation of 5α-reductase inhibitors and drugs for treating benign prostatic hyperplasia, and belongs to the field of traditional Chinese medicines. Background technique [0002] BPH (benign prostatic hyperplasia, BPH) is prostate hypertrophy, which is a common disease that seriously affects elderly men. It is characterized by static obstruction caused by benign prostatic hyperplasia and dynamic obstruction caused by increased prostate smooth muscle tension. Manifested as bladder urine outflow obstruction, urgency, frequency, and residual urine, often leading to urinary tract infection and even induced nephritis. Although BPH itself is not a life-threatening disease in the near future, it obviously affects the physical activity and social ability of patients, thereby affecting their quality of life and causing great pain t...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P13/08
Inventor 高小平邹文俊刘忠荣李伯刚
Owner CHENGDU DIAO PHARMA GROUP
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