Methods for intradermal delivery of therapeutics agents

A technology for therapeutic agents and dermis, applied in the field of intradermal delivery of therapeutic agents, can solve the problems of no indication of pharmacokinetic advantages, no teaching, etc., to achieve the effects of improving drug effects, saving doses, and improving bioavailability

Inactive Publication Date: 2006-11-22
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this reference does not teach to imply selective dermal administration, nor does it imply any possible pharmacokinetic advantages that such selective administration might yield

Method used

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  • Methods for intradermal delivery of therapeutics agents
  • Methods for intradermal delivery of therapeutics agents
  • Methods for intradermal delivery of therapeutics agents

Examples

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Embodiment Construction

[0056] The present invention provides methods for administering one or more biologically active agents, preferably therapeutic agents, to the skin of a subject, wherein the biologically active agents are delivered to the intradermal region of the subject's skin. The present invention is based in part on the inventors' unexpected discovery that when these therapeutic agents are delivered to the intradermal region, they are rapidly transported to the local lymphatic system as compared to conventional modes of delivery, including subcutaneous and intramuscular delivery, thereby providing Benefits published in this article. While not wishing to be bound by a particular mechanism of action, therapeutic agents delivered according to the methods of the present invention are transported in vivo through the local lymphatic system into the systemic blood systemic circulation and deep tissue milieu.

[0057] The present invention provides improved methods for the delivery of biologically...

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Abstract

The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents, such as therapeutic agents, through lymphatic vasculature accessed by intradermal delivery. Therapeutic agents to be delivered in accordance with the present invention include, but are not limited ton antineoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenesis agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present invention have improved bioavailability, including improved systemic distribution and improved delivery to particular tissues. Therapeutic agents, delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over convention drug delivery methods including dose sparing, increased drug efficacy, reduced side effects, reduced metastatic potential and prolonged survival.

Description

[0001] This application claims priority to US Provisional Application No. 60 / 550,197, filed March 3, 2004, and US Provisional Application No. 60 / 497,702, filed August 26, 2003, which are hereby incorporated by reference in their entirety. 1. Field of invention [0002] The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, to the intradermal compartment of the skin of a subject. The present invention provides improved methods of delivering biologically active agents, such as therapeutic agents, to the lymphatic vasculature by intradermal delivery. Therapeutic agents that can be delivered in accordance with the present invention include, but are not limited to, anti-neoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenic agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K45/00
Inventor R·J·佩蒂斯A·哈维R·坎普贝尔J·米克兹塔J·布里廷汉姆
Owner BECTON DICKINSON & CO
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