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Composition containing reduced coenzyme q

A composition and reduced technology, which is applied in the direction of chemical change-inhibiting compositions, drug combinations, non-active ingredients of polymer compounds, etc., can solve problems such as instability, unclear soluble method of reduced coenzyme Q, and poor solubility

Active Publication Date: 2006-11-29
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Reduced coenzyme Q 10 Due to its own antioxidant activity, reduced coenzyme Q 10 Drug administration is a substance whose usefulness to the above-mentioned diseases is expected to be great, but as its physical properties, since it is an extremely unstable substance that is automatically oxidized when exposed to air, and its solubility in water is also extremely poor, Therefore, it has not been available for industrial use until now.
[0011] It has been reported that reduced coenzyme Q 10 A formulation utilizing liposome coatings (Kishi et al., 1999, BioFactors, 10, 131-138) was made. The liposomes used were the examples of the existing preparations for each test. The method of solubilization of the prototype Coenzyme Q is not at all clear

Method used

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  • Composition containing reduced coenzyme q
  • Composition containing reduced coenzyme q
  • Composition containing reduced coenzyme q

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Dissolve 205g of γ-cyclodextrin in 1336ml of water, and immediately add 18g of reduced coenzyme Q 10 (contains 2% oxidized coenzyme Q 10 ), was stirred at 10000rpm by a homogenizer for 20 minutes to prepare reduced coenzyme Q 10 The cyclodextrin mixture is used for spray drying to obtain powder composition I. The molar ratio of the constituent raw materials of the powder composition is reduced coenzyme Q 10 : γ-cyclodextrin = 1:8.

Embodiment 2

[0061] Thoroughly stir 12.2g of ascorbic acid in 675ml of water and dissolve, then dissolve 85.3g of γ-cyclodextrin, and immediately add 15g of reduced coenzyme Q 10 (contains 2% oxidized coenzyme Q 10 ), was stirred at 10000rpm by a homogenizer for 20 minutes to prepare reduced coenzyme Q 10 The cyclodextrin mixture is used for spray drying to obtain powder composition II. The molar ratio of the constituent raw materials of the powder composition is reduced coenzyme Q 10 :γ-cyclodextrin:ascorbic acid=1:4:4.

Embodiment 3

[0063]12.2g of ascorbic acid was thoroughly stirred and dissolved in 1188ml of water, then 171g of γ-cyclodextrin was dissolved, and 15g of reduced coenzyme Q was added immediately 10 (contains 2% oxidized coenzyme Q 10 ), was stirred at 10000rpm by a homogenizer for 20 minutes to prepare reduced coenzyme Q 10 The cyclodextrin mixture is used for spray drying to obtain powder composition III. The molar ratio of the constituent raw materials of the powder composition is reduced coenzyme Q 10 :γ-cyclodextrin:ascorbic acid=1:8:4.

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PUM

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Abstract

A composition containing a reduced coenzyme Q which can be stored for a long time in a cold atmosphere and also at room temperature and further is soluble in water can be prepared by a method comprising contacting or mixing a reduced coenzyme Q with cyclodextrin, to thereby form an inclusion compound, or mixing an antioxidant, a reduced coenzyme Q and cyclodextrin under suitable conditions. The above method has allowed the provision of a reduced coenzyme Q, which is susceptible to auto-oxidation and is lipophilic and therefore has not been utilized commercially in the past, in the form of a composition which can be stably stored and be soluble in water.

Description

technical field [0001] The present invention provides a reduced coenzyme Q-containing composition excellent in solubility or dispersibility in water and excellent in storage stability as a raw material for foods, functional foods, pharmaceuticals, or quasi-drugs (quasi-drugs), and The composition does not use natural emulsifiers or synthetic emulsifiers, liposomes, etc. that are commonly used. Background technique [0002] Coenzyme Q is an essential component widely distributed in organisms from bacteria to mammals, and is known to be a constituent of the electron transport system of mitochondria in cells in organisms. Coenzyme Q is known to have an antioxidant effect in addition to its role as a transport component in the electron transport system through repeated oxidation and reduction in mitochondria. Human coenzyme Q consists of coenzyme Q with 10 repeats in the side chain 10 It is the main component, and usually 40% to 90% of coenzyme Q exists in the reduced form in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61K9/14A61K47/04A61K47/12A61K47/18A61K47/20A61K47/22A61K47/40A61K47/42A61P3/00A61P39/06A61P43/00A23L1/30C09K15/08A61K9/16
CPCA61K9/1652A23V2002/00A61K31/09A61P3/00A61P3/10A61P39/06A61P43/00A61P9/04A61P9/10A23V2250/314
Inventor 田中穗积藤井健志川辺泰三
Owner KANEKA CORP