A composite preparation for treating HP (helicobacter pylori)
A Helicobacter pylori preparation technology, applied in the field of drugs for the treatment of Helicobacter pylori, to achieve the effect of increasing AUC, increasing blood drug concentration, and reducing drug resistance rate
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Embodiment 1
[0037] Enteric-coated tablet prescription containing 20 mg of active ingredients omeprazole and 250 mg of clarithromycin per tablet:
[0038] Omeprazole 20g
[0039] Clarithromycin 250g
[0040] Mannitol 65g
[0041] Lactose 45g
[0042] Poloxamer 1g
[0043] PVP 6g
[0046] Acrylic No. 2 Resin 5g
[0047] Appropriate amount of diethyl phthalate
[0048] Specific preparation method:
[0049] Put 20 g of omeprazole, 250 g of clarithromycin, 65 g of mannitol, and 45 g of lactose through a 100-mesh sieve into a KJz-10 type fast stirring granulator and mix at high speed for 2 minutes, and dissolve 1 g of poloxamer in Add 15ml of 5% PVP in absolute ethanol solution as a binder. Quickly mix for 3 minutes. Quickly granulate for 2 minutes. Take it out and dry it in a vacuum oven for 4 hours. Sieve the granules with a 16-mesh sieve and add an appropriate amount of magnesium stearate. , pressed into plain tablets. Add ta...
Embodiment 2
[0051] Prescription of enteric-coated tablets containing 20 mg of active ingredients omeprazole and 500 mg of clarithromycin per tablet:
[0052] Omeprazole 20g
[0053] Clarithromycin 500g
[0054] Mannitol 65g
[0055] Lactose 45g
[0056] Poloxamer 1g
[0057] PVP 6g
[0060] Acrylic No. 2 Resin 5g
[0061] Appropriate amount of diethyl phthalate
[0062] Preparation:
[0063] With this prescription, basically according to the preparation method of Example 1, a total of 1000 omeprazole clarithromycin enteric-coated tablets were produced, each containing 10 mg of omeprazole and 500 mg of clarithromycin.
Embodiment 3
[0065] Prescription for each capsule containing the active ingredients omeprazole 20mg and clarithromycin 250mg:
[0066] Omeprazole 20g
[0067] Clarithromycin 250g
[0068] Mannitol 60g
[0069] Lactose 40g
[0070] Poloxamer 1.5g
[0071] PVP 6g
[0072] Magnesium stearate 8g
[0074] Acrylic No. 2 Resin 5g
[0075] Appropriate amount of diethyl phthalate
[0076] Specific preparation method:
[0077] Preparation of omeprazole enteric-coated granules: Take 20 g of omeprazole, 60 g of mannitol, and 40 g of lactose that have been passed through a 100-mesh sieve and place them in a KJz-10 type fast stirring granulator for 2 minutes at high speed, and mix the poloxamer Dissolve about 1g of poloxamer in 15ml of 5% PVP absolute ethanol solution as a binder, add, mix quickly for 3 minutes, granulate quickly for 2 minutes, take it out, dry in a vacuum oven for 4 hours, and use a 24-40 mesh sieve whole grain. Add talc powder into 5% PVP absolute e...
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