An injection containing phenylpropanolid glycosides, its preparation method and use

A technology containing phenylpropanoid glycosides and phenylpropanoid glycosides, which is applied in the field of medicine and can solve problems such as large dosage, complex components of injection water needles, and inconvenient use

Inactive Publication Date: 2006-12-13
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Duyiwei tablets and Duyiwei capsules recorded in the Chinese Pharmacopoeia in 2000, it is an oral preparation directly processed from the whole herb or root of a single plant Duyiwei. Chinese patent application No. 02134169.9 patent discloses a Duyiwei dispersible tablets, but these three preparations are all made from the unique water extract, which has the disadvantage of taking a large amount. Generally, it needs to take 3 capsules orally once, each 300mg, three times a day, which is equivalent to 9g crude drug
Chinese Patent Application No. 200410070710.8 patent discloses a unique injection, which is directly extracted from the unique plant with ethanol, and the extract has complex components, not the effective part of the unique, let alone the active ingredient
Therefore, the composition of the water injection needle made in this way is complex, so the pre-treatment process is relatively complicated, which will also lead to poor stability of the finished product
[0004] At present, there is no unique powder injection dosage form, but in actual application, water for injection has special requirements for storage conditions, and temperature, oxygen and light all have a great influence on its quality stability. Inconvenience

Method used

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  • An injection containing phenylpropanolid glycosides, its preparation method and use
  • An injection containing phenylpropanolid glycosides, its preparation method and use
  • An injection containing phenylpropanolid glycosides, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1. Weigh 10 kg of the unique medicinal material coarse powder, add 100 kg of water and decoct for 2 hours, add 100 kg of water to the dregs of the medicine and decoct for 2 hours, combine the decoction, concentrate to a relative density of about 1.09, add ethanol to adjust the alcohol concentration to 70% , stand still. After the precipitation was complete, the supernatant was filtered and concentrated to a relative density of about 1.08. Pass this concentrated solution through WLD macroporous resin. After the concentrated solution passes through the resin column completely, rinse the resin column with 20% ethanol until the eluent is nearly colorless, and then wash the adsorbed substances on the resin column with 80% ethanol. Remove and collect the ethanol eluate. The solution after recovering ethanol under reduced pressure is adsorbed by a polyamide column with a particle size of 120-200 mesh, eluted with a gradient of 30% ethanol to 85%, and the eluate of 40-...

Embodiment 2

[0078] Weigh 10kg of the coarse powder of the unique medicinal material, add 40% ethanol and 80kg of reflux extraction for 3 times, combine the ethanol extracts, recover ethanol, concentrate the medicinal solution to a relative density of 1.02, add an appropriate amount of water to mix and stir evenly, and let stand. After the precipitation is complete, pour out the supernatant, filter, and concentrate the medicinal solution to a relative density of about 1.04. Pass the concentrated solution through HPD-450 macroporous resin. After the concentrated solution passes through the resin column, rinse the resin column with water until the eluent is nearly colorless, and continue to elute the adsorbed substances on the resin column with 40% ethanol. , and collect the ethanol eluate. The solution after recovering ethanol under reduced pressure is adsorbed by a polyamide column with a particle size of 80-200 mesh, eluted with a gradient of 30% ethanol to 85%, and the eluate of 40-85% e...

Embodiment 3

[0080] Weigh 10kg of the coarse powder of the unique medicinal material, add 100kg of 80% ethanol to reflux extraction for 3 times, combine the ethanol extracts, recover the ethanol, concentrate the medicinal solution to a relative density of 1.08, add an appropriate amount of water to mix and stir evenly, and let stand. After the precipitation is complete, pour out the supernatant, filter, and concentrate the medicinal solution to a relative density of about 1.08. Pass this concentrated solution through HPD-100 macroporous resin. After the concentrated solution has passed through the resin column, rinse the resin column with 20% ethanol until the eluate is nearly colorless, and then use 80% ethanol to remove the adsorbed substances on the resin column. Perform elution and collect the ethanol eluate. The solution after recovering ethanol under reduced pressure is adsorbed by a polyamide column with a particle size of 120-200 mesh, eluted with a gradient of 30% ethanol to 95%, ...

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Abstract

The invention relates the injection containing propyl benzene glycosides and preparing method. The method comprises the following steps: using labiate as raw material, extracting it, separating it, getting medicinal findings, and getting solution injection or sterilized powder agent for injection. The solution injection contains 10-20mg propyl benzene glycosides per mg, and the sterilized powder agent for injection contains 20-40mg propyl benzene glycosides per mg. The invention has the advantages of high curative effect and quality.

Description

Technical field [0001] The invention belongs to the field of medicine, and in particular relates to an injection made from phenylpropanoid glycosides extracted and separated from a single plant as a raw material as the main active ingredient. The invention also relates to the preparation method and application of the injection. Background technique [0002] Unique flavor is the dry whole herb of Lamiophlomis ratata (Benth.) Kudo, the unique flavor of Lamiophlomis ratata (Benth.) Kudo. For bruises, traumatic bleeding. It has the function of promoting blood circulation to relieve pain, removing blood stasis and stopping bleeding, and is used for incision pain after various surgical operations. Bleeding, surgical fractures, sprains, rheumatic arthralgia, metrorrhagia, dysmenorrhea, gingival swelling, bleeding, etc. The usual dosage is 2-3g crude drug. [0003] Duyiwei tablets and Duyiwei capsules recorded in the Chinese Pharmacopoeia in 2000, it is an oral preparation direc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K31/7028A61K9/08A61K9/14A61P29/00A61P7/04A61P19/08A61P1/02
Inventor 陈文俊陈路林刘菊妍宁德山吴德玄李吉来
Owner GUANGZHOU HANFANG PHARMA
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