Method for establishing anti-hepatitis C virus drug screening experimental animal model

A hepatitis C virus and drug technology, applied in the field of establishing anti-hepatitis C virus drug screening, can solve the problems of low model success rate, simple genotype, and low virus concentration, and achieve the effect of high model success rate
CN1879894AInactive Publication Date: 2006-12-20李卫云
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
李卫云
Publication Date
2006-12-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for selecting anti-hepatitis C medicine, which injects the artifical hepatitis C virus into tree mouse with negative hepatitis C, to build the hepatitis C natural infection model; via following steps as (1) composing hepatitis C virus; (2) injecting it into normal tree mouse, while the virus carried amount of each animal is higher than 105c; (3) fixing the hepatitis C virus naturally to infect the tree mouse model; (40 using the mouse model with positive hepatitis C virus to select the anti- hepatitis C medicine.
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Description

technical field

[0001] The present invention relates to the field of hepatitis C virus. Specifically, the invention relates to a method for establishing anti-hepatitis C virus drug screening and an experimental animal model. Background technique

[0002] About 170 million people worldwide are infected with hepatitis C virus (HCV) (Alter M, 1997). The infection rate in developed countries is nearly 2%, and the HCV natural infection rate in my country is about 2-3%, which belongs to the high infection area of ​​HCV (Wen Yumei, 1999). 70-80 of acute hepatitis C patients will develop into chronic hepatitis, and 5-10 of them will develop into liver cirrhosis and liver cancer (Jin Qi, 2001). Since Choo et al. successfully cloned and isolated HCV in 1989, the molecular biology research of HCV has made great progress. So far known HCV has 6 genotypes and more than 30 subtypes. However, because the cell receptor of HCV has not been fully determined, lack of efficient cell culture...

Claims

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