Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for extracting diaryl heptane compounds from galangas

A technology for diarylheptane and galangal, applied in the field of extracting diarylheptane compounds from galangal, can solve problems such as no public reports on anti-Candida albicans, and achieve less loss of active components and extraction simple craftsmanship

Inactive Publication Date: 2006-12-27
TIANJIN UNIV
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no public report about extracting anti-Candida albicans effective chemical components from galangal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting diaryl heptane compounds from galangas
  • Method for extracting diaryl heptane compounds from galangas
  • Method for extracting diaryl heptane compounds from galangas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The method for extracting diaryl heptane compound 7-(4-hydroxyphenyl)-1-phenyl 4-ene-3-heptanone from Galanga, comprises the steps:

[0027] (1) 1 kg of galangal medicinal material was pulverized (purchased from Tianjin Chinese Herbal Pieces Factory in March 2004, identified by the Pharmacy Teaching and Research Office of Tianjin Medical University), added 4 kg of 95% ethanol aqueous solution, heated and refluxed for 6 hours , filter the extract, extract 2 times, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.10 at 50°C, add distilled water 4 times the mass of the extract to dissolve, extract 3 times with chloroform, and extract the extract under reduced pressure Concentrate, and separate the concentrated extract by silica gel column chromatography, using a gradient of petroleum ether-ethyl acetate with a volume ratio of 4:1, 3:1, 2:1, 1:1, 1:2, 1:3 After elution, a total of 33 components of AO0101-AO0133 were obtained;

[00...

Embodiment 2

[0032] The method for extracting diaryl heptane compound 7-(4-hydroxyphenyl)-1-phenyl-4-ene-3-heptanone from Galanga, comprises the steps:

[0033] (1) 1 kilogram of galangal medicinal material is pulverized, and 6 kilograms of vol. percent concentration is 75% ethanol aqueous solution, heated and refluxed for 5 hours, the extract is filtered, extracted 3 times, and the filtrate is concentrated under reduced pressure to 50 DEG C when the relative density is 1.05 extract, add 5 times of the extract mass to dissolve in distilled water, extract 2 times with chloroform, concentrate the extract under reduced pressure, separate the concentrated extract through silica gel column chromatography, and use a volume ratio of 4: 1, 3:1, 2:1, 1:1, 1:2, 1:3 petroleum ether-ethyl acetate gradient elution, a total of 33 components of AO0101-AO0133 were obtained;

[0034] (2) Combine the AO0110 and AO0111, perform silica gel column chromatography, and elute with chloroform-methanol with a volume ...

Embodiment 3

[0036] The method for extracting diaryl heptane compound 7-(4-hydroxyphenyl)-1-phenyl 4-ene-3-heptanone from Galanga, comprises the steps:

[0037] (1) 1 kg of galanga medicinal material is pulverized, and 2 kg of ethanol aqueous solution with a concentration of 98% by volume is added, heated and refluxed for 7 hours, the extract is filtered, extracted once, and the relative density of the filtrate is concentrated under reduced pressure to 50°C. 1.20 extract, add distilled water with 3 times the mass of the extract to dissolve, extract 4 times with chloroform, concentrate the extract under reduced pressure, separate the concentrated extract through silica gel column chromatography, and use a volume ratio of 4: 1, 3:1, 2:1, 1:1, 1:2, 1:3 petroleum ether-ethyl acetate gradient elution, a total of 33 components of AO0101-AO0133 were obtained;

[0038] (2) Combine the AO0110 and AO0111, perform silica gel column chromatography, and elute with chloroform-methanol with a volume rati...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an extracting method of diaryl heptanes compound from lesser galangal, which comprises the following steps: extracting lesser galangal through alcohol; condensing filtrate; dissolving the concrete through water; extracting through trichloromethane; separating the extract liquid through silica gel column chromatography method; eluting through ligarine-phenyl-methyl acetate gradient to obtain 33 compositions; combining 10th and 11th compositions; proceeding silica gel column chromatography and eluting chloroform-carbinol; combining similar compositions through TLC to obtain six compositions; proceeding Toyopearl HW-40C column chromatography for 3rd composition to obtain six compositions; preparing HPLC for the second composition at inversed-phase; eluting through 95:5 carbinol and water; separating to obtain 2 compositions with 7-(4- hydroxyphenyl)-1- phenyl -4-alkylene-3- heptanone.

Description

technical field [0001] The invention relates to a method for extracting compounds from traditional Chinese medicines, in particular to a method for extracting diarylheptane compounds from galangal. Background technique [0002] The traditional Chinese medicine galangal is one of the commonly used traditional Chinese medicines. It has the effects of warming the stomach, expelling wind, dispersing cold, promoting qi and relieving pain. It is widely used in seasoning among the people. Clinically, it is often used in the treatment of cold pain in the abdomen, cold stomach and vomiting, indigestion, acid regurgitation and other diseases. Modern chemical and pharmacological studies have shown that galangal has complex chemical components, strong pharmacological activity, and strong anti-ulcer, anti-diarrhea, choleretic, analgesic, anti-inflammatory, anti-hypoxic, anti-coagulant, and anti-thrombotic effects. It has been clinically proven for many years that galangal has definite ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/172C07C45/78A61K36/9062A61K125/00
Inventor 蒋伶活段宏泉吕玮
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com