Preparation of compound Danshen tablets

A compound Danshen tablet and a technology for a manufacturing method are applied in the field of traditional Chinese medicine manufacturing for treating cardiovascular diseases, and can solve the problems of inability to guarantee drug efficacy, large dosage of drugs, inconvenient use and the like

Inactive Publication Date: 2007-01-17
MASSON GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The above literature shows that the manufacturing method according to the Pharmacopoeia cannot guarantee the content of active ingredients in Compound Danshen Tablets, that is, the quality cannot be guaranteed, which directly leads to the inability to guarantee the efficacy of the medicine.
The use of supercritical carbon dioxide to extract Danshen is only to fully extract the fat-soluble components such as tanshinone IIA in Danshen, that is, it cannot fully extract all the active ingredients in Danshen, so the supercritical carbon dioxide extraction process alone cannot To ensure its quality and efficacy, this is the first, and the second is that the notoginseng recorded in the Pharmacopoeia is used as a medicine in fine powder, which also causes a large dosage of the medicine and is inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] [Recipe] Danshen 1350g, Panax notoginseng 423g, borneol 24g

[0064] The present invention takes Danshen medicinal material, pulverizes it into coarse powder, puts it into a supercritical extraction kettle, extracts at 25Mpa at extraction pressure, at 40°C at extraction temperature, at 6Mpa at analysis pressure, at 45°C at analysis temperature, at a flow rate of 10 L / h of carbon dioxide, and at a rate of 2 mL / h of ethanol as an entrainer. min, the extraction time is 3 hours, the extract is concentrated under reduced pressure to an extract with a relative density of 1.40 (55-60°C); extract the salvia miltiorrhiza residue after supercritical extraction with water twice, add 10 times the amount of water for the first time, 70 Reflux for 2 hours at ℃, filter; add 10 times the amount of water for the second time, reflux at 70°C for 2 hours, filter, combine the filtrates and concentrate under reduced pressure to a concentrated solution with a relative density of 1.20 (55-60°C)...

Embodiment 2

[0066] [Recipe] Danshen 1350g, Panax notoginseng 423g, borneol 24g

[0067] The present invention takes Danshen medicinal material, grinds it into coarse powder, puts it into a supercritical extraction kettle, extracts at 15Mpa at an extraction temperature of 30°C, analyzes at a pressure of 1Mpa, and analyzes at a temperature of 35°C. Min, extraction time 2h, the extract was concentrated under reduced pressure to extract with a relative density of 1.20 (55°C); the supercritically extracted salvia miltiorrhiza slag was extracted twice with water, and 6 times the amount of water was added for the first time, and refluxed at 55°C 1 hour, filter; add 5 times the amount of water for the second time, reflux at 55°C for 1 hour, filter, combine the filtrates and concentrate under reduced pressure to a concentrated solution with a relative density of 1.10 (55°C), add ethanol until the amount of ethanol is 50 %, let stand for 12 hours, take the supernatant, and concentrate to an extract...

Embodiment 3

[0069] [Recipe] Danshen 1350g, Panax notoginseng 423g, borneol 24g

[0070] The present invention takes Danshen medicinal material, grinds it into coarse powder, puts it into a supercritical extraction kettle, extracts at 45Mpa at an extraction pressure, at an extraction temperature of 60°C, at an analysis pressure of 10Mpa, at an analysis temperature of 60°C, a carbon dioxide flow rate of 15L / h, and an entrainer ethanol flow rate of 5mL / h. min, the extraction time is 5 hours, the extract is concentrated under reduced pressure to an extract with a relative density of 1.40 (60°C); extract the salvia miltiorrhiza after supercritical extraction with water twice, add 15 times the amount of water for the first time, and reflux at 100°C 3 hours, filter; add 15 times the amount of water for the second time, reflux at 100°C for 3 hours, filter, combine the filtrates and concentrate under reduced pressure to a concentrated solution with a relative density of 1.30 (60°C), add ethanol unt...

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Abstract

A process for preparing the compound danshin tablet includes such steps as extracting the liposoluble component containing danshinone from red sage root by supercritical CO2, extracting danshinolic acid by a alcohol deposition method, extracting arasaponin from notoginseng by alcohol, mixing them with starch, drying, granulating, adding borneol powder, stirring, die pressing and coating.

Description

technical field [0001] The invention relates to traditional Chinese medicine pharmacy, in particular to a manufacturing method of traditional Chinese medicine for treating cardiovascular diseases. Background technique [0002] The traditional Chinese medicine Compound Danshen Tablets has been recorded in the 1985, 1990, 2000, and 2005 editions of the "Pharmacopia of the People's Republic of China". The preparation method is also documented. According to the preparation method in the 2005 edition of the Pharmacopoeia: Danshen 1350g, Panax notoginseng 423g, borneol 24g, Danshen ginseng was heated to reflux with ethanol for 1.5 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to an appropriate amount. After 1.5 hours, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount, and set aside: decoct the dregs with water for 2 hours, filter the decoction, and concentrate the filtrate to an appropria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/28A61P9/00A61P9/10A61K31/045
Inventor 程朝晖胡耀昌杨承鸿侯峰莫启武金波刘汉槎
Owner MASSON GROUP
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