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Process for preparing micro crystal cellulose milk sugar

A microcrystalline cellulose and lactose technology, which is applied in the preparation of microcrystalline cellulose lactose and the preparation of pharmaceutical excipients, can solve the problems such as the limitation of the production and promotion of microcrystalline cellulose lactose, the complicated production technology of microcrystalline cellulose lactose and the like. , to achieve the effect of improving production conditions, eliminating cumbersome procedures and saving costs

Active Publication Date: 2007-01-24
SHANDONG LIAOCHENG E HUA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the production technology of microcrystalline cellulose lactose is very complicated, each auxiliary material used must be strictly screened, its stability and safety, and whether the auxiliary materials are chemically inert need to be strictly inspected and carefully selected. Therefore, The production and promotion of microcrystalline cellulose lactose are limited
After searching, there is no method for producing microcrystalline cellulose lactose that is suitable for national conditions, simple in technology, and has independent intellectual property rights.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Add process water into the reaction tank, heat the steam to 100°C for 15 minutes, cool to 50°C, and set aside;

[0040] (2) In terms of weight ratio, according to the ratio of microcrystalline cellulose: lactose: process water = 1: 3: 8.7, microcrystalline cellulose and lactose are dropped into the reaction tank, and stirred for 2 hours with an emulsifier to make emulsified slurry;

[0041] (3) discharge the slurry of 2% of the total weight of the slurry from the outlet of the reaction tank, then add it back into the reaction tank, continue to stir for 30 minutes, until the sampling inspection slurry is milky white, even colloid;

[0042] (4) Use spray drying equipment to dry the product of step (3) at a temperature of 110° C., pick up the material once every 30 minutes and transfer it to the screening and packaging process;

[0043] (5) After the product passes through a 100-mesh sieve, it becomes the finished product of microcrystalline cellulose lactose.

Embodiment 2

[0045] (1) Add 1300 kg of process water to the reaction tank, heat it with steam to 100°C for 15 minutes, and cool it to 50°C for later use.

[0046] (2) drop into microcrystalline cellulose 150kg, 450 kilograms of lactose in retort, stir 2 hours, emit 30-50 kilograms of slurry from outlet and return to retort again, continue to stir for 30 minutes, the slurry of sampling inspection is milky white, uniform colloid, Transfer to the next procedure.

[0047] (3) Debug the spray drying equipment in a normal state, and control the drying temperature within the range of 100-120°C for drying. The material is picked up every 30 minutes and transferred to the screening and packaging process.

[0048] (4) After the product passes through a 100-mesh sieve, each package is 20kg and becomes a finished product of microcrystalline cellulose lactose.

Embodiment 3

[0050] (1) Add process water into the reaction tank, heat the steam to 100°C for 20 minutes, cool to 50°C, and set aside;

[0051] (2) In terms of weight ratio, according to the ratio of microcrystalline cellulose: lactose: process water = 1: 3.2: 9, microcrystalline cellulose and lactose are dropped into the reaction tank, stirred for 3 hours with an emulsifier, and emulsified slurry;

[0052](3) discharge the slurry of 3% of the total weight of the slurry from the outlet of the reaction tank, then add it back into the reaction tank, continue to stir for 50 minutes, until the sampling inspection slurry is milky white, even colloid;

[0053] (4) Use spray drying equipment to dry the product of step (3) at a temperature of 110-120° C., pick up the material once every 30 minutes and transfer it to the screening and packaging process;

[0054] (5) After the product passes through a 100-mesh sieve, it becomes the finished product of microcrystalline cellulose lactose.

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Abstract

The preparation process of microcrystal cellulose milk sugar includes the following steps: steam heating water in reaction pot and cooling to 50deg.c; adding microcrystal cellulose and milk sugar to the reaction pot in the material ratio of microcrystal cellulose, milk sugar and water of 1 to 2.7-3.2 to 8.5-9, and stirring with emulsifying machine until forming homogeneous colloid; spray drying at 100-120deg.c, and 100 mesh sieving to obtain microcrystal cellulose milk sugar product. Thus prepared microcrystal cellulose milk sugar product is used for forming, adhering, filling, preventing adhesion and adsorbing and as adhesive and filler for direct tabletting mainly.

Description

technical field [0001] The invention relates to a preparation method of pharmaceutical excipients, in particular to a preparation method of microcrystalline cellulose lactose, belonging to the technical field of pharmacy. Background technique [0002] Pharmaceutical excipients refer to the substances added to maintain the stability, safety or homogeneity of pharmaceutical preparations when they are formed, or to adapt to the characteristics of the preparations for the purpose of promoting dissolution and sustained release. They are the necessary basis for the development of pharmaceuticals. The 2005 edition of "Chinese Pharmacopoeia" is divided into 15 categories according to the use of pharmaceutical excipients, namely: acidifiers, antifoaming agents, adsorbents, antimicrobial preservatives, antioxidants, coloring agents, ointment bases, sweeteners, flavorings Agents, solvents, alkalizing agents, skin penetration enhancers, excipients, surfactants, pharmaceutical excipients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38
Inventor 尹健杨春风路汉文
Owner SHANDONG LIAOCHENG E HUA PHARM CO LTD
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