Disease model animal expressing MEGSIN/RAGE/iNOS and method of evaluating compound with the use of the animal

A technology of disease models and compounds, applied in biochemical equipment and methods, chemical instruments and methods, disease diagnosis, etc., can solve problems such as unsatisfactory needs
CN1913774AInactive Publication Date: 2007-02-14RENASCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RENASCI
Publication Date
2007-02-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

A triple Tg (megsin / RAGE / iNOS-Tg) is constructed by crossing a megsin-Tg with an RAGE / iNOS-Tg. It is found out that this megsin / RAGE / iNOS-Tg suffers from the onset of remarkable diabetic kidney lesion at an early stage which has never been observed so far and shows various uniform lesion images such as glomerular enlargement. It is also found out that the animal showing these symptoms is useful as a model animal of diabetic nephropathy. That is to say, the disease model animal as described above overexpresses megsin gene, receptor for advanced glycation end product gene and inducible nitric oxide synthase gene and, therefore, suffers from renal dysfunction associated with glomerular disorders at an early stage.
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Description

technical field

[0001] The present invention relates to a disease model animal, in particular, a model animal with renal dysfunction (for example, diabetic nephropathy) for hyperglycemia, and a model animal with renal dysfunction for glomerulopathy. The present invention also relates to a method for evaluating the curative effect of the compound on renal dysfunction by using the disease model animal. Background technique

[0002] In recent years, due to the gradual westernization of lifestyle and diet, the number of diabetic patients has increased steadily. Diabetes is a disease in which persistent hyperglycemia causes various tissue disorders (called complications) throughout the body. In addition to the so-called macrovascular complications such as coronary arteriosclerosis and cerebrovascular disorders, pathological symptoms characteristic of diabetes arise: retinopathy, neuropathy and nephropathy, collectively referred to as "three major complications". In particular, ...

Claims

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