Unlock instant, AI-driven research and patent intelligence for your innovation.

Remedy for hypertension

A technology for hypertension and intracranial pressure, applied in the field of hypertension treatment drugs, can solve problems such as undetermined influence and increased intracranial pressure

Inactive Publication Date: 2007-02-14
ASTELLAS PHARMA INC +1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are reports of increasing intracranial pressure (non-patent document 4), reports of not increasing intracranial pressure (non-patent document 5), and reports of not increasing intracranial pressure (non-patent document 6). The effect of Dipin on intracranial pressure in patients with intracranial hemorrhage has not been established

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Heat about 2L of distilled water to 50-60°C, and add 2.5 g of nicardipine hydrochloride and 125 g of sorbitol while stirring to dissolve it. After cooling the solution (pH about 4.5) to room temperature, the pH was adjusted to 3.5 with 0.1 M hydrochloric acid. Next, distilled water was added so that the total amount became 2.5 L, and after filtering with a filter, 5 mL was filled into brown ampoules (ampoules). Similarly, the nicardipine hydrochloride liquid preparation was prepared in the following manner: [(nicardipine low-dosage preparation) 2mL preparation: nicardipine hydrochloride 2mg, D-sorbitol 100mg, pH regulator, transparent micro Yellow, pH3.0-4.5, osmotic pressure ratio about 1.0 (ratio to normal saline)], [10mL preparation: nicardipine hydrochloride 10mg, D-sorbitol 500mg, pH regulator, transparent light yellow, pH3.0~4.5, osmotic pressure ratio about 1.0 (ratio to normal saline)], [(Nicardipine high dosage preparation) 25mL preparation: Nicardipine hydroch...

experiment example

[0043] Male rats (240-290 g) with natural onset of hypertension were used to create a temporary cerebral ischemia and reperfusion model by nylon rope method under halide halide anesthesia. Reperfusion was performed 6 hours after the introduction of cerebral ischemia. After 1 hour after reperfusion, normal saline (n=6), high-dose nicardipine preparations (n=6) or nicardipine were continuously administered. Cardipin low dose formulations (n=6). Intracranial pressure (ICP) was measured using a brain-embedded ICP detector manufactured by Kamino, and the regional cerebral blood flow in the ischemic center was measured using a laser Doppler flowmeter. The rectal temperature was maintained at 37±0.5°C. A katheter is placed in the femoral artery to measure blood pressure and blood gas analysis is performed.

[0044] As a result, the ICP during ischemia was 6.7±0.5 mmHg, but it was deliberately increased to 13±1 mmHg after 1 hour of reperfusion (p<0.05). The mean arterial pressure d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

It is intended to eliminate the restricted indication in the cases with elevated intracranial pressure in the acute stage of cerebral attack to which nicardipine or its salt has been contraindicated. It is found out for the first time that, in cerebral infarct model rats, nicardipine or its salt would not affect the intracranial pressure, different from the common recognition, even in a group with elevated intracranial pressure in the acute stage of onset. Namely, a remedy for hypertension for patients with elevated intracranial pressure in the acute stage of cerebral attack which contains, as the active ingredient, nicardipine or its salt.

Description

technical field [0001] The invention relates to a drug for treating hypertension. Specifically, it relates to a new use of a drug for treating hypertension containing nicardipine and its salt as an active ingredient. Background technique [0002] Nicardipine and its salts have the effects of increasing cerebral blood flow, increasing coronary blood flow, and lowering blood pressure. They have been marketed as therapeutic drugs for hypertension (Belupi is only registered as a trademark injection, and Yamanouchi Pharmaceutical Co., Ltd. limited company). Its function is the emergency treatment of abnormal hypertension during operation, hypertensive emergency (hypertensive emergency), acute heart failure, etc. The contraindications for its use include: patients with intracranial hemorrhage presumed to be incomplete hemostasis, patients with increased intracranial pressure in the acute stage of cerebral apoplexy, and others (Non-Patent Document 1). The reason is that it has t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4422A61P9/12
CPCA61K31/4422A61P9/12A61P25/00A61P43/00
Inventor 片山容一铃木雅德林明日香
Owner ASTELLAS PHARMA INC