Ginkgo ketone ester dropping pill and its prepn process

A technology of ginkgo ketone ester and ginkgo ketone, which is applied in the field of ginkgo ketone ester dripping pills and its preparation, can solve the problems of affecting the dissolution and absorption of lactones and flavonoids, and the low dispersion of fine powder, so as to improve the absorption speed and bioavailability , drug stability improvement, and the effect of expanding the user population

Inactive Publication Date: 2007-03-21
北京汉典中西药研究开发中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the ginkgolides in the ginkgo esters are insoluble in water, and the aglycone components in the flavonoids are also insoluble in water, the granules made are suspended granules, and the fine powder of the ginkgo esters has a low dispersion, which affects the lactones. and the dissolution and absorption of flavonoids; at the same time, with the continuous development of preparation technology, new dosage forms that are more conducive to disease treatment continue to emerge, while the drop pills in the current formulations of ginkgo ketone esters on the market are still blank; combined with the priority of the disease, One formulation is not enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Ginkgo ketone ester 8g, polyethylene glycol 400027g, polyethylene glycol 60009g

[0038] Put polyethylene glycol 4000 and polyethylene glycol 6000 in a stainless steel container according to the prescription, heat to 90-100°C, add ginkgo ketone ester fine powder after they are completely melted, stir to make them even, transfer them to a liquid storage bottle, 80 Insulation at -85°C, dripping conditions: dripper diameter 3mm / 4mm, drop distance 6-8cm, adjust the drip valve (drip speed is about 50 drops per minute), drop into liquid paraffin at 5-10°C, Drain the formed drop pills and wipe off the liquid paraffin to make 1000 drop pills.

Embodiment 2

[0039] Embodiment 2: Ginkgo ketone ester 2g, polyethylene glycol 4000 18.4g, polyethylene glycol 6000 4.6g

[0040] Put polyethylene glycol 4000 and polyethylene glycol 6000 in a stainless steel container according to the prescription, heat to 80-90 ° C, add ginkgo ketone ester fine powder after they are completely melted, stir to make them even, transfer them to a liquid storage bottle, 70 Insulation at -80°C, the dripping conditions are: the diameter of the dripper is 3.5mm / 4.5mm, the drop distance is 6-8cm, the dripping valve is adjusted (the dripping speed is about 50 drops per minute), and methyl alcohol at 5-10°C is dripped. In the silicone oil, drain the formed drop pills and wipe off the methyl silicone oil, collect the drop pills, and obtain.

Embodiment 3

[0041] Embodiment 3: Ginkgo ketone ester 5g, polyethylene glycol 4000 10g, polyethylene glycol 6000 5g

[0042] Put polyethylene glycol 4000 and polyethylene glycol 6000 in a stainless steel container according to the prescription, heat to 100-110°C, add ginkgo ketone ester fine powder after they are completely melted, stir to make them even, transfer them to a liquid storage bottle, 85 Insulation at -90°C, dripping conditions: dropper diameter 3mm / 4mm, drop distance 4-6cm, adjust the drip valve (drip speed is about 50 drops per minute), drop 5-10°C simethicone In the process, drain the formed drop pills and wipe off the simethicone oil, collect the drop pills, and obtain.

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PUM

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Abstract

The present invention relates to one kind of ginkgo ketone ester dripping pill and its preparation process, and belongs to the field of Chinese medicine technology. The ginkgo ketone ester dripping pill is prepared mainly with ginkgo ketone ester and medicinal matrix, which is preferably the mixture of polyglycol-4000 and polyglycol-6000. The ginkgo ketone ester dripping pill preparation has ideal treating effect on apoplexy and coronary heart disease caused by blood stasis, and possesses the advantages of quick absorption, high bioavailability, small dosage, several taking modes, low production cost, determined curative effect, etc.

Description

technical field [0001] The invention relates to a ginkgo ketone ester dripping pill for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases are the number one killer of human health, and have the characteristics of high morbidity, high mortality, and high disability rate. . According to reports, 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, and one person dies from such diseases every 12 seconds. Therefore, prevention and treatment of cardiovascular and cerebrovascular diseases have become a serious and arduous task before us. topic. In this battle against cerebral ischemic injury, Ginkgo biloba preparations have emerged and attracted worldwide attention. With the continuous development of medicine and chemical industry, ginkgo ketone ester, the main active ingredient ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/16A61K9/20A61P9/00A61P9/10
Inventor 林德良
Owner 北京汉典中西药研究开发中心
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