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Component concentration measuring device and method of controlling component concentration measuring device

A concentration measurement and concentration technology, applied in measurement devices, blood characterization devices, analysis materials, etc., can solve the problems of photoacoustic signal intensity change, flat frequency characteristics, etc.

Active Publication Date: 2007-03-28
NIPPON TELEGRAPH & TELEPHONE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0048] The practicability of the above-mentioned high-frequency intensity modulation obtained by using the intermittent plate 617 rotated by a motor described in the second conventional example is also a subject of research, but for ultrasonic waves with a wavelength of 10 mm or less than 2.5 mm, because the wavelength is close to Due to the element size of commonly used ultrasonic detectors, it is very difficult to realize a detector that is prone to standing waves and has a flat frequency characteristic.
There is a problem that the intensity of the photoacoustic signal changes every measurement due to such a change in pressing pressure.

Method used

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  • Component concentration measuring device and method of controlling component concentration measuring device
  • Component concentration measuring device and method of controlling component concentration measuring device
  • Component concentration measuring device and method of controlling component concentration measuring device

Examples

Experimental program
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Embodiment 1

[0584] (Embodiment 1 (the first))

[0585] In the blood component concentration measuring device of the embodiment shown in FIG. 1 , it is also effective to use a laser light source as the first light source 101 and the second light source 105 . When selecting a laser source, it is first necessary to estimate the necessary output power level.

[0586] There is a permissible limit of light intensity in the light exposure to the human body. Generally, JISC6802 stipulates that 1 / 10 of the intensity that can cause harm to 50% of individuals is the maximum allowable amount. In the continuous irradiation of non-visible infrared light (wavelength of 0.8 μm or more), the maximum allowable amount is 1mW / 1mm 2 .

[0587] In Example 1, the blood component to be measured is blood sugar, and the wavelength of light to be irradiated is 1.6 μm. Based on the principle described above, the modulation frequency f is 150 kHz or more. Here, the wavelength λ=c / f of the photoacoustic signal gene...

Embodiment 2

[0628] (Embodiment 2 (the first))

[0629] Example 2 is a type of detection of backward propagation of sound waves propagating in the retrograde direction of the irradiated light. The structure of Embodiment 2 is shown in FIG. 10. In the structure of Embodiment 1 of the blood component concentration measuring device shown in FIG. During this period, the surface on one side of the acoustic coupler 512 is in contact with the part to be inspected of the living body 510, and the light multiplexed by the wave combiner 509 from the surface on the other side of the acoustic coupler 512 is incident, and the incident light passes through the acoustic coupler 512, It is irradiated to the living body to be inspected part 510 . Here, the ultrasonic detector 513 is disposed on the side where the multiplexed light is incident on the acoustic coupler 512 .

[0630] In addition, the difference between the operation of the blood component concentration measuring device of Embodiment 2 and th...

Embodiment 3

[0647] In Example 1 and Example 2, an example about the blood glucose concentration, that is, the blood sugar level was shown. However, as components constituting blood, besides glucose, various components such as lipids including cholesterol, proteins, and inorganic components are included. In Embodiment 3, an example in which the blood component concentration measuring device and the blood component concentration measuring device control method of Embodiment 1 are applied to cholesterol is shown. It should be noted that the blood component concentration measuring device and the control method of the blood component concentration measuring device of this embodiment can be similarly applied to Embodiment 2, Embodiment 3, Embodiment 4, Embodiment 5, and Embodiment 6 described later. .

[0648] Figure 11 shows the absorbance of water at wavelengths from 1200 nm to 2500 nm. Figure 12 shows the absorbance of cholesterol from 1600 nm to 2600 nm. According to the spectrum shown i...

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Abstract

A non-invasive component concentration measuring device capable of an accurate measurement by tracking a change in the sensitivity characteristics of a photo-acoustic signal detector to always allow measurement at high-sensitivity frequency, and a method of controlling a component concentration measuring device. The component concentration measuring device is characterized by comprising a light generating means for generating two-wave lights having different wavelengths, a light modulating means for electrically intensity-modulating respective two-wave lights having different wavelengths at the same frequency by an inverse-phase signal, a light outputting means for outputting the intensity-modulated two-wave lights having different wavelengths toward a specimen, and a sound wave detecting means for detecting a sound wave produced in the specimen by output lights.

Description

technical field [0001] The present invention relates to a non-invasive component concentration measuring device and a control method of the component concentration measuring device, and particularly relates to a non-invasive measuring device and a measuring method which non-invasively take glucose as a blood component as the measurement object, and its concentration is the blood sugar level. Background technique [0002] As methods for measuring non-invasive component concentrations, various methods based on irradiation of electromagnetic waves through the skin or observation of radiation have been tried so far. All of these utilize the interaction of glucose molecules with electromagnetic waves of specific wavelengths, that is, absorption or scattering, in the case of target blood components, such as blood sugar levels. [0003] However, the interaction between glucose and electromagnetic waves is small, and the intensity of electromagnetic waves that can be safely irradiat...

Claims

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Application Information

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IPC IPC(8): A61B5/145G01N21/00G01N29/00
CPCA61B5/1455G01N21/1702A61B5/14532A61B5/0095
Inventor 长沼和则田岛卓郎冈部勇一须藤昭一
Owner NIPPON TELEGRAPH & TELEPHONE CORP
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