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The application relates to a device control method, an insulin infusion device, a program product and a closed-loop infusion system, which are applied to an insulin infusion device, the insulin infusion device comprising a touch screen, at least one memory and at least one processor, the touch screen being used for receiving user input, the memory storing executable instructions, and the processor being used for executing the executable instructions to realize the following method: monitoring whether a blood glucose influencing event occurs during operation of a closed-loop operation mode; the blood glucose influencing event comprises an event that a user's blood glucose level deviates from a target blood glucose range of a control parameter due to device operation and / or user activity; in the case that it is determined that the blood glucose influencing event occurs, triggering a safety protection program; and performing safety management on the closed-loop operation mode of the insulin infusion device through the safety protection program.