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Infantile heat-clearing and antitussive dispersing tablets

A dispersible tablet, children's technology, applied in the direction of aluminum/calcium/magnesium active ingredients, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., can solve adhesion, difficult industrialization, and collapse of traditional Chinese medicine dispersible tablets Solving problems such as difficulty in controlling the speed, achieving the effect of improving the disintegration rate and having a large room for maneuver

Inactive Publication Date: 2011-10-26
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most compound Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. Most of the drugs contain macromolecular substances such as pectin and polysaccharides, which adhere to the surface when the TCM dispersible tablet disintegrates, which has a negative impact on the disintegration and dissolution of the drug.
[0012] To sum up, most of the compound Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets at 3 due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. The requirement within minutes is more difficult to industrialize than Western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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  • Infantile heat-clearing and antitussive dispersing tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The traditional Chinese medicine raw materials of Xiaoer Qingre Zhike Dispersible Tablets: 90 grams of ephedra, 120 grams of bitter almonds, 270 grams of gypsum, 90 grams of licorice, 180 grams of skullcap, 180 grams of Radix Radix, and 90 grams of Bean Root.

[0054] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Xiaoer Qingre Zhike Dispersible Tablets: 27% of fine powder of Xiaoer Qingre Zhike extract, 20% of pregelatinized starch, 30% of microcrystalline cellulose, 7% of low-substituted hydroxypropyl cellulose, Lactose 10%, polyvinylpyrrolidone 4%, micronized silica gel 1%, magnesium stearate 1%.

[0055] Xiaoer Qingre Zhike Dispersible Tablets are obtained according to the following specific steps: add ephedra and gypsum with 10 times the amount of water and boil for half an hour, then add five flavors such as bitter almonds, then add 8 times the amount of water and boil twice, 2 hours each time, combine The decoction is fil...

Embodiment 2

[0058] 35% by weight of fine powder of Xiaoer Qingrezhike extract, 21% sodium carboxymethylcellulose, 15% cross-linked polyvinylpyrrolidone, 10% microcrystalline cellulose, 5% polyvinylpyrrolidone, 7% lactose, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0060] 40% by weight of fine powder of Xiaoer Qingre Zhike extract, 21% sodium carboxymethyl starch, 15% croscarmellose sodium, 4% low-substituted hydroxypropyl cellulose, 3% cross-linked polyvinylpyrrolidone , mannitol 6%, polyvinylpyrrolidone 7%, micronized silica gel 2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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Abstract

A dispersing tablet for baby to treat cold and cough is prepared from 7 Chinese-medicinal materials including gypsum, liquorice root, scutellaria root, bitter apricot kernel, etc.

Description

technical field [0001] The invention relates to the technical field of dispersible tablets of Chinese patent medicines, in particular to a dispersible tablet for clearing away heat and relieving cough of children with cold medicine. Background technique [0002] Dispersible tablets are a new dosage form of medicine developed in recent years. There are many dosage forms for clearing heat and relieving cough in children. Xiaoer Qingre Zhike Oral Liquid, one of the original dosage forms, has been included in the 2005 edition of Chinese Pharmacopoeia (Part II). Although the oral liquid is convenient for children to use, it is inconvenient in terms of packaging, transportation, storage, etc. due to the instability of certain components in water, which will precipitate after being left for a long time. [0003] One of the original dosage forms, Xiaoer Qingre Zhike Granules or ordinary tablets, has slow dissolution, poor absorption and low bioavailability. [0004] Compared with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K36/17A61K33/06A61K36/19A61K36/315A61K36/484A61K36/481A61K36/59A61K9/20A61P11/14
Inventor 罗晓健王跃生吕爱平杨世林饶毅张爱玲游剑
Owner JIANGXI HERBFINE HI TECH
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