Sandwich structure magnetic composite micro ball with functional shell layer, its preparing method and use

A technology of magnetic composite microspheres and sandwich structure, which can be applied to the preparation methods of peptides, biochemical equipment and methods, chemical instruments and methods, etc., and can solve problems such as insufficient magnetic characteristics.

Inactive Publication Date: 2007-04-11
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcoming of the structural design of the above-mentioned microspheres is that they cannot introduce enough magnetic components, so their magnetic characteristics are not prominent enough.

Method used

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  • Sandwich structure magnetic composite micro ball with functional shell layer, its preparing method and use
  • Sandwich structure magnetic composite micro ball with functional shell layer, its preparing method and use

Examples

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preparation example Construction

[0024] The preparation process of the magnetic composite microsphere of the present invention is divided into two stages: the first stage is to prepare the magnetic polymer composite microsphere with the core-shell structure of Chinese patent application 200510087784.7; the second stage is to prepare the magnetic composite microsphere with the core-shell structure. The polymer composite microsphere is the initial material, which is covered with one or two types of functionalized shell layers.

[0025] The coating method of the functionalized shell varies according to the category it belongs to. Even in the same category, due to the different specific materials, the specific formulation processes used are different. The coating methods of various functionalized shells can be summarized as follows:

[0026] The first type: Generally, magnetic polymer composite microspheres with a core-shell structure are dispersed in a solution of the polymer to be coated. Relying on interacti...

Embodiment 1

[0063] PS / Fe 3 o 4 / SiO 2 Preparation of Magnetic Composite Microspheres (Method 1)

[0064] Ultrasonically disperse 0.01g of magnetic composite microspheres from Reference Example 4 into 100mL of absolute ethanol, adjust the pH value of the system to 9 with ammonia water, and keep the temperature in a constant temperature water bath at 40°C; then add 0.1mL of orthosilicic acid dropwise Ethyl alcohol solution (the volume ratio of ethyl orthosilicate and ethanol is 1:1), kept constant temperature, and reacted for 12 hours under the action of mechanical stirring. After the reaction is completed, the product is separated by using a magnetic field, washed several times with absolute ethanol, and finally dispersed in absolute ethanol for cold storage. The transmission electron micrograph of the composite microsphere is shown in Fig. 1 .

Embodiment 2

[0066] PS / Fe 3 o 4 / SiO 2 Preparation of Magnetic Composite Microspheres (Method 2)

[0067] Ultrasonic dispersion of 0.25g of magnetic composite microspheres from Reference Example 6 into 100mL of isopropanol was added to 7mL of ammonia water (concentration of 25%), and the temperature was kept constant in a constant temperature water bath at 40°C; then a certain amount of ethyl orthosilicate was added ester, make the concentration of ethyl orthosilicate in the system 4.0mmol / L, keep constant temperature, and react for 12 hours under the action of mechanical stirring. After the reaction is completed, the product is separated by using a magnetic field, washed several times with absolute ethanol, and finally dispersed in absolute ethanol for cold storage. The specific saturation magnetization of the product was 15.2 emu / g.

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Abstract

The invention discloses a type of sandwich structure magnetic composite microspheres with functional shells. Said magnetic composite microspheres in structure is characterized by the whole body is as sandwich structure, kernel is as macromolecule microspheres, the middle layer is as magnetic nanoparticles, the external layer is as functional shells of certain thickness.

Description

field of invention [0001] The invention relates to a class of sandwich-structured magnetic composite microspheres with a functionalized shell, a preparation method and application thereof, and belongs to the field of novel magnetic functional composite materials. Background technique [0002] As a new class of functional composite materials, magnetic composite microspheres have increasingly extensive and important applications in cell separation, protein purification, nucleic acid extraction, clinical diagnosis, targeted drug delivery, and immobilized enzymes. [0003] Since the emergence of magnetic composite microspheres in the late 1970s, they have developed rapidly in the past 30 years. Various magnetic microspheres that have been listed in the literature have been sold as products in the market. In terms of the composition of magnetic composite microspheres, inorganic materials such as silica and polymer materials such as polystyrene have been tried as matrix materials,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/32C12N5/00C07K1/14C07H21/00
Inventor 刘正平贺昌城杜江于艳丽武英
Owner BEIJING NORMAL UNIVERSITY
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