Buprenorphin and/or buprenorphin hydrochloride plaster substrate and its preparing method for plaster

A technology of buprenorphine hydrochloride patch and buprenorphine hydrochloride, which is applied in the field of preparation of patch matrix and patch, can solve the problem of blood drug concentration peak and peak valley fluctuation, poor analgesic effect, and many adverse reactions And other issues

Inactive Publication Date: 2007-04-11
哈尔滨健迪医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the defects of peak and peak and valley fluctuations in blood concentration, many adverse reactions and poor analgesic effect during the administr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0004] Specific embodiment one: The buprenorphine and / or buprenorphine hydrochloride patch matrix of this embodiment includes a pharmaceutical ingredient, an adhesive and an organic solvent; the pharmaceutical ingredient is buprenorphine and / or buprenorphine hydrochloride as a patch 0.5% to 40.0% of the mass of the matrix, the adhesive accounts for 40% to 90% of the mass of the patch matrix, and the balance is an organic solvent.

[0005] The buprenorphine and / or buprenorphine hydrochloride patch matrix of this embodiment has good compatibility and adhesion with the skin. Long-term stability tests have proved the active ingredient content, in vitro release and adhesion characteristics of the matrix No significant changes occurred, indicating that the matrix has good stability.

Example Embodiment

[0006] Specific embodiment two: this embodiment is different from specific embodiment one in that: the buprenorphine and / or buprenorphine hydrochloride patch matrix also includes a plasticizer that accounts for 0.1%-20% of the mass of the patch matrix , 0.1%-20% thickener, 0.1%-20% transdermal absorption enhancer and / or 0.1%-10% crystallization inhibitor. Others are the same as the first embodiment.

[0007] The area in this embodiment is 5~60cm 2 The daily drug delivery rate of the patch matrix is ​​0.5~7.5mg.

Example Embodiment

[0008] Specific embodiment three: this embodiment is different from specific embodiment one in that the adhesive is polyisobutylene pressure sensitive adhesive, silicone rubber pressure sensitive adhesive, polyacrylate pressure sensitive adhesive or acrylic pressure sensitive adhesive. Others are the same as the first embodiment.

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PUM

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Abstract

Buprenorphine and or buprenorphine hydrochloride patch base material and preparation for said patch is presented, relating to a patch base material and preparation there of. Its preparation process is: 1) after mixing evenly Buprenorphine and or buprenorphine hydrochloride, adhesive and organic solvent, spreadin thereof evenly on lining cloth; 2) after drying, spreading protective film on to the other side of base material to obtain hereinabove said patch.

Description

technical field [0001] The invention relates to a patch matrix and a preparation method thereof. Background technique [0002] Buprenorphine is a partial opioid receptor agonist synthesized in the 1960s. It is a non-narcotic analgesic. Its analgesic ability is about 30 times higher than that of morphine and about 75 times higher than that of pentazocine. Times, and widely used to reduce cancer pain and postoperative pain and assist anesthesia, can be used as a powerful analgesic drug and heroin addiction detoxification treatment. But at present buprenorphine and / or buprenorphine hydrochloride preparations have the defects of peak and peak and valley fluctuations in blood concentration, many adverse reactions, and poor analgesic effect during the administration of buprenorphine hydrochloride preparations. Contents of the invention [0003] The purpose of the present invention is to solve the defects of peak and peak and valley fluctuations in blood concentration, many adve...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K9/70A61K47/34A61K47/32A61K47/12A61K47/10A61P25/04
Inventor 徐静张艳红
Owner 哈尔滨健迪医药技术有限公司
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